PMID- 27321094
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20180730
IS  - 0017-0011 (Print)
IS  - 0017-0011 (Linking)
VI  - 87
IP  - 4
DP  - 2016
TI  - Is there an association between the development of metabolic syndrome in PCOS 
      patients and the C677T MTHFR gene polymorphism?
PG  - 246-53
LID - 10.17772/gp/61751 [doi]
AB  - INTRODUCTION: Polycystic ovary syndrome (PCOS) is the most common endocrine 
      disorder in women of reproductive age. PCOS is characterized by anovulation, 
      polycystic ovaries, hyperandrogenism leading to infertility, dermatological and 
      psychological problems, as well as the risk of developing Metabolic Syndrome 
      (MetS) and cardiovascular disease (CVD). The exact cause of PCOS remains unclear. 
      Various biochemical and genetic markers have been implicated in predisposition to 
      PCOS, but no single variant has been associated with the syndrome. Some authors 
      connect hyperhomocysteinemia (HHcy) with MetS and its components. The MTHFR gene 
      C677T polymorphism is a common genetic abnormality leading to 
      hyperhomocysteinemia. OBJECTIVES: The aim of the study was to confirm the 
      existence of a possible correlation between metabolic disturbances in PCOS and 
      the MTHFR C677T polymorphism. MATERIAL AND METHODS: A total of 98 patients 
      diagnosed with PCOS according to the Rotterdam criteria and 101 age-matched 
      healthy controls were included in the study. Genotyping of MTHFR C677T was 
      performed by the real time PCR method. RESULTS: Statistically significant 
      differences were observed between those two groups with regard to body mass index 
      (BMI), waist circumference (WC), hip circumference (HC), fasting insulin, total 
      cholesterol (TC), and triglycerides (TG). No significant differences in the 
      prevalence of the genotypes of the MTHFR C677T gene polymorphism were found 
      between the PCOS group and controls. Despite the lack of significant differences, 
      we observed a tendency for a higher prevalence of the TT genotype in the PCOS 
      group (p = 0.06). No statistically significant differences were observed between 
      the PCOS group and the control group in terms of the presence of the MetS 
      components and the predisposition to develop MetS. CONCLUSIONS: Our study did not 
      confirm an association between the MTHFR C677T gene polymorphism and the 
      development of MetS in PCOS. Further studies with larger sample size might be 
      useful to determine this association.
FAU - Ozegowska, Katarzyna
AU  - Ozegowska K
AD  - k.ozegowska@gmail.com.
FAU - Bogacz, Anna
AU  - Bogacz A
FAU - Bartkowiak-Wieczorek, Joanna
AU  - Bartkowiak-Wieczorek J
FAU - Seremak-Mrozikiewicz, Agnieszka
AU  - Seremak-Mrozikiewicz A
FAU - Pawelczyk, Leszek
AU  - Pawelczyk L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Ginekol Pol
JT  - Ginekologia polska
JID - 0374641
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Polycystic Ovary Syndrome/*genetics
MH  - *Polymorphism, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Young Adult
OTO - NOTNLM
OT  - gene polimorphism
OT  - metabolic syndrome
OT  - methylenetetrahydrofolate reductase
OT  - polycystic ovary syndrome
EDAT- 2016/06/21 06:00
MHDA- 2018/07/31 06:00
CRDT- 2016/06/21 06:00
PHST- 2016/05/23 00:00 [received]
PHST- 2016/05/23 00:00 [accepted]
PHST- 2016/06/21 06:00 [entrez]
PHST- 2016/06/21 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
AID - VM/OJS/J/47282 [pii]
AID - 10.17772/gp/61751 [doi]
PST - ppublish
SO  - Ginekol Pol. 2016;87(4):246-53. doi: 10.17772/gp/61751.