PMID- 27321206
OWN - NLM
STAT- MEDLINE
DCOM- 20170407
LR  - 20170817
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 42
IP  - 4
DP  - 2016 Sep
TI  - Adverse effects of weight loss: Are persistent organic pollutants a potential 
      culprit?
PG  - 215-23
LID - S1262-3636(16)30418-9 [pii]
LID - 10.1016/j.diabet.2016.05.009 [doi]
AB  - Health professionals commonly recommend weight loss to individuals with obesity. 
      However, unexpected adverse health effects after a weight-loss program have been 
      reported in several studies. The factors that could explain this phenomenon are 
      currently poorly understood. However, one potential factor that has emerged is 
      persistent organic pollutants (POPs). Due to their lipophilic nature, POPs are 
      known to accumulate in the adipose tissue and their concentrations are found to 
      be higher in obese individuals than lean subjects. There is evidence to suggest 
      that weight loss induces a significant increase in POPs levels in the 
      bloodstream. Furthermore, the increases in plasma POPs levels after weight loss 
      are even greater with an intensive weight loss. Thus, a critical question that 
      remains unresolved is whether POPs released from the adipose tissue to the 
      bloodstream during intensive weight loss could increase the risk of 
      cardiometabolic disturbances. In turn, the accumulation of POPs released in 
      response to an intensive weight loss may impair energy metabolism and stimulate a 
      subsequent weight regain. Thus, the purpose of this review is to provide insights 
      about the role of POPs on cardiometabolic risk factors during weight loss and 
      weight regain that could potentially explain, at least in part, the adverse 
      effects observed in certain weight-loss studies. We will also discuss the 
      potential synergistic or antagonistic POPs-dependent risks following weight-loss 
      programs. Ultimately, this may lead in establishing new therapeutic boundaries to 
      minimize potential health hazards related to weight loss.
CI  - Copyright (c) 2016 Elsevier Masson SAS. All rights reserved.
FAU - Cheikh Rouhou, M
AU  - Cheikh Rouhou M
AD  - Department of Biological Sciences, Universite du Quebec a Montreal, H3C 3P8 
      Montreal, Canada.
FAU - Karelis, A D
AU  - Karelis AD
AD  - Department of Exercise Science, Universite du Quebec a Montreal, C.P. 8888, 
      Succursale centre-ville, H3C 3P8 Montreal, Canada. Electronic address: 
      karelis.antony@uqam.ca.
FAU - St-Pierre, D H
AU  - St-Pierre DH
AD  - Department of Exercise Science, Universite du Quebec a Montreal, C.P. 8888, 
      Succursale centre-ville, H3C 3P8 Montreal, Canada.
FAU - Lamontagne, L
AU  - Lamontagne L
AD  - Department of Biological Sciences, Universite du Quebec a Montreal, H3C 3P8 
      Montreal, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160616
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adipose Tissue/drug effects/metabolism
MH  - Animals
MH  - Energy Metabolism/drug effects
MH  - Environmental Pollutants/pharmacokinetics/*toxicity
MH  - Humans
MH  - Obesity/metabolism/therapy
MH  - Organic Chemicals/pharmacokinetics/*toxicity
MH  - Weight Loss/drug effects/*physiology
OTO - NOTNLM
OT  - Cardiometabolic risk factors
OT  - Dioxins
OT  - Organochlorine pesticides
OT  - Polychlorinated biphenyls
OT  - Weight regain
EDAT- 2016/06/21 06:00
MHDA- 2017/04/08 06:00
CRDT- 2016/06/21 06:00
PHST- 2016/03/23 00:00 [received]
PHST- 2016/05/09 00:00 [revised]
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/06/21 06:00 [entrez]
PHST- 2016/06/21 06:00 [pubmed]
PHST- 2017/04/08 06:00 [medline]
AID - S1262-3636(16)30418-9 [pii]
AID - 10.1016/j.diabet.2016.05.009 [doi]
PST - ppublish
SO  - Diabetes Metab. 2016 Sep;42(4):215-23. doi: 10.1016/j.diabet.2016.05.009. Epub 
      2016 Jun 16.