PMID- 27321249
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20171203
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
VI  - 35
DP  - 2016 Nov
TI  - Daytime sleepiness is associated with hyperhomocysteinemia in rural area of 
      China: A cross-sectional study.
PG  - 73-77
LID - S0953-6205(16)30165-0 [pii]
LID - 10.1016/j.ejim.2016.05.029 [doi]
AB  - OBJECTIVE: To ascertain whether sleep abnormalities including daytime sleepiness, 
      snoring, apnea, sleep disruption and sleep duration abnormity are significantly 
      associated with hyperhomocysteinemia (Hhcy). METHODS: A total of 5992 
      participants were involved in the cross-sectional study. Sleep abnormalities were 
      evaluated by a structured questionnaire. Hhcy was defined as plasma levels of 
      homocysteine >/=15mum/L. RESULTS: After adjustment for age, gender, education, 
      current smoking status and current drinking status, daytime sleepiness (OR, 
      1.597; 95%CI, 1.210-2.110, P=0.001), sleep duration <6h (OR, 1.273; 95%CI, 
      1.063-1.524, P=0.009) and sleep duration >8h (OR, 1.205; 95%CI, 1.065-1.364, 
      P=0.003) were significantly associated with Hhcy. While snoring (OR, 1.065; 
      95%CI, 0.950-1.195, P=0.279), apnea (OR, 1.170; 95%CI, 0.924-1.482, P=0.193), and 
      sleep disruption (OR, 1.065; 95%CI, 0.852-1.331, P=0.580) were not. After further 
      adjustment for body mass index, low-density lipoprotein cholesterol, high-density 
      lipoprotein cholesterol, triglyceride, total cholesterol, physical activity, 
      diabetes, coronary heart disease, stroke, depression, glomerular filtration rate, 
      hypertension and hyperuricemia, still the increased OR could be found in the 
      daytime sleepiness group (OR, 1.569; 95%CI, 1.145-2.150, P=0.005). However, sleep 
      duration <6h (OR, 1.067; 95%CI, 0.788-1.445, P=0.676) and sleep duration >8h 
      groups (OR, 1.080; 95%CI, 0.883-1.320, P=0.453) were no longer significantly 
      associated with Hhcy. CONCLUSIONS: Daytime sleepiness, but not sleep duration 
      abnormity, snoring, apnea and sleep disruption was an independent risk factor for 
      Hhcy.
CI  - Copyright (c) 2016 European Federation of Internal Medicine. Published by Elsevier 
      B.V. All rights reserved.
FAU - Zhang, Naijin
AU  - Zhang N
AD  - Department of Cardiology, The First Hospital of China Medical University, 
      Shenyang, PR China. Electronic address: 1640917750@qq.com.
FAU - Chen, Shuang
AU  - Chen S
AD  - Department of Cardiology, The First Hospital of China Medical University, 
      Shenyang, PR China. Electronic address: 535883890@qq.com.
FAU - Chen, Yintao
AU  - Chen Y
AD  - Department of Cardiology, The First Hospital of China Medical University, 
      Shenyang, PR China. Electronic address: 905058009@qq.com.
FAU - Guo, Xiaofan
AU  - Guo X
AD  - Department of Cardiology, The First Hospital of China Medical University, 
      Shenyang, PR China. Electronic address: 348061760@qq.com.
FAU - Sun, Guozhe
AU  - Sun G
AD  - Department of Cardiology, The First Hospital of China Medical University, 
      Shenyang, PR China. Electronic address: gzhsun66@163.com.
FAU - Qian, Hao
AU  - Qian H
AD  - Department of Cardiology, The First Hospital of China Medical University, 
      Shenyang, PR China. Electronic address: qianhaocmu@126.com.
FAU - Sun, Yingxian
AU  - Sun Y
AD  - Department of Cardiology, The First Hospital of China Medical University, 
      Shenyang, PR China. Electronic address: yxsun@mail.cmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160616
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apnea/epidemiology
MH  - China
MH  - Coronary Disease/*complications
MH  - Cross-Sectional Studies
MH  - Disorders of Excessive Somnolence/blood/*epidemiology
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sex Factors
MH  - *Sleep
MH  - Snoring/epidemiology
MH  - Stroke/*complications
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - Hyperhomocysteinemia
OT  - Sleep abnormalities
OT  - Stroke
EDAT- 2016/06/21 06:00
MHDA- 2017/08/18 06:00
CRDT- 2016/06/21 06:00
PHST- 2016/02/20 00:00 [received]
PHST- 2016/05/14 00:00 [revised]
PHST- 2016/05/29 00:00 [accepted]
PHST- 2016/06/21 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
PHST- 2016/06/21 06:00 [entrez]
AID - S0953-6205(16)30165-0 [pii]
AID - 10.1016/j.ejim.2016.05.029 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2016 Nov;35:73-77. doi: 10.1016/j.ejim.2016.05.029. Epub 2016 
      Jun 16.