PMID- 27324271
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20190606
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 22
DP  - 2016 Jun 21
TI  - Predictive Values of Red Blood Cell Distribution Width in Assessing Severity of 
      Chronic Heart Failure.
PG  - 2119-25
AB  - BACKGROUND This retrospective study was performed to evaluate the value of 
      baseline red blood cell distribution width (RDW) for predicting the severity of 
      chronic heart failure (CHF) compared with N-terminal prohormone brain natriuretic 
      peptide (NT-ProBNP) and other hematological and biochemical parameters. MATERIAL 
      AND METHODS Hematological and biochemical parameters were obtained from 179 
      patients with New York Heart Association (NYHA) CHF class I (n=44), II (n=39), 
      III (n=41), and IV (n=55). Receiver operator characteristic (ROC) curves were 
      used for assessing predictive values. RESULTS RDW increased significantly in 
      class III and IV compared with class I (14.3+/-2.3% and 14.3+/-1.7% vs. 12.9+/-0.8%, 
      P<0.01). Areas under ROCs (AUCs) of RDW and NT-ProBNP for class IV HF were 0.817 
      and 0.840, respectively. RDW was markedly elevated in the mortality group 
      compared with the survival group (13.7+/-1.7 vs. 15.8+/-1.8, P<0.01). The predictive 
      value of RDW was lower than that of NT-ProBNP but was comparable to white blood 
      cell (WBC), neutrophil (NEU), lymphocyte (L), and neutrophil/lymphocyte ratio 
      (N/L) for mortality during hospitalization, with AUCs of 0.837, 0.939, 0.858, 
      0.891, 0.885, and 0.885, respectively. RDW and NT-proBNP showed low predictive 
      values for repeated admission (>/=3). RDW was an independent risk factor for 
      mortality (OR=2.531, 95% CI: 1.371-4.671). CONCLUSIONS RDW increased 
      significantly in class III and IV patients and in the mortality group. The 
      predictive value of RDW is comparable to NT-proBNP for class IV and lower than 
      that of NT-proBNP for mortality. Elevated RDW is an independent risk factor for 
      mortality.
FAU - Liu, Sen
AU  - Liu S
AD  - Department of Cardiology, Affiliated Weihai Central Hospital of Weifang Medical 
      College, Wendeng, Shandong, China (mainland).
FAU - Wang, Ping
AU  - Wang P
AD  - Department of Cardiology, Affiliated Weihai Central Hospital of Weifang Medical 
      College, Wendeng, Shandong, China (mainland).
FAU - Shen, Ping-Ping
AU  - Shen PP
AD  - Department of Cardiology, Affiliated Weihai Central Hospital of Weifang Medical 
      College, Wendeng, Shandong, China (mainland).
FAU - Zhou, Jian-Hua
AU  - Zhou JH
AD  - Department of Cardiology, Affiliated Weihai Central Hospital of Weifang Medical 
      College, Wendeng, Shandong, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20160621
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Erythrocyte Count/methods
MH  - Erythrocyte Indices/*physiology
MH  - Female
MH  - Heart Failure/*blood/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC4920102
EDAT- 2016/06/22 06:00
MHDA- 2017/03/16 06:00
PMCR- 2016/06/21
CRDT- 2016/06/22 06:00
PHST- 2016/06/22 06:00 [entrez]
PHST- 2016/06/22 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/06/21 00:00 [pmc-release]
AID - 898103 [pii]
AID - 10.12659/msm.898103 [doi]
PST - epublish
SO  - Med Sci Monit. 2016 Jun 21;22:2119-25. doi: 10.12659/msm.898103.