PMID- 27324541
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20200808
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 18
IP  - 6
DP  - 2016 Jun
TI  - [Role of triggering receptor expressed on myeloid cells-1 in the pathogenesis of 
      Kawasaki disease].
PG  - 522-6
AB  - OBJECTIVE: To study the role of triggering receptor expressed on myeloid 
      cells-1(TREM-1) in the pathogenesis of Kawasaki disease (KD). METHODS: Based on 
      color Doppler examination results, 45 children with KD were classified into two 
      groups: coronary artery lesions (CAL group) and no coronary artery lesions (NCAL 
      group). Fifteen children with fever caused by respiratory infection (fever 
      control group) and fifteen healthy children (normal control group) served as 
      controls. Real-time fluorescence quantitative PCR was used to detect the 
      expression of TREM-1 mRNA and DNAX-activating protein 12 (DAP12) mRNA in 
      peripheral blood mononuclear cells (PBMC). ELISA was used to detect the 
      expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), 
      DAP12, monocyte chemoattractant protein-1(MCP-1), interleukin-8 (IL-8) proteins 
      levels. RESULTS: The mean serum protein concentrations of sTREM-1 and DAP12 and 
      the expression levels of TREM-1 mRNA and DAP12 mRNA in PBMC in 45 children with 
      KD (KD group) were significantly higher than in the two control groups (P<0.05). 
      The levels of sTREM-1 protein and TREM-1 mRNA in the CAL subgroup were 
      significantly higher than in the NCAL subgroup (P<0.05). The serum protein 
      concentrations of MCP-1 and IL-8 in the KD group were significantly higher than 
      in the two control groups (P<0.05). The MCP-1 protein level in the CAL subgroup 
      was significantly higher than in the NCAL subgroup (P<0.05). In children with KD, 
      there was a positive correlation between serum sTREM-1 and MCP-1 levels (r=0.523, 
      P<0.05). CONCLUSIONS: TREM-1 activation may be involved in the development of KD.
FAU - Zhao, Jian-Mei
AU  - Zhao JM
AD  - Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, 
      Jiangsu 226001, China. 2687084388@qq.com.
FAU - Wang, Qian
AU  - Wang Q
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TREM1 protein, human)
RN  - 0 (Triggering Receptor Expressed on Myeloid Cells-1)
SB  - IM
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Interleukin-8/blood
MH  - Male
MH  - Membrane Glycoproteins/blood/genetics/*physiology
MH  - Mucocutaneous Lymph Node Syndrome/*etiology/immunology
MH  - RNA, Messenger/analysis
MH  - Receptors, Immunologic/blood/genetics/*physiology
MH  - Triggering Receptor Expressed on Myeloid Cells-1
PMC - PMC7389080
EDAT- 2016/06/22 06:00
MHDA- 2016/09/16 06:00
PMCR- 2016/06/15
CRDT- 2016/06/22 06:00
PHST- 2016/06/22 06:00 [entrez]
PHST- 2016/06/22 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
PHST- 2016/06/15 00:00 [pmc-release]
AID - 10.7499/j.issn.1008-8830.2016.06.011 [pii]
AID - zgddekzz-18-6-522 [pii]
AID - 10.7499/j.issn.1008-8830.2016.06.011 [doi]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jun;18(6):522-6. doi: 
      10.7499/j.issn.1008-8830.2016.06.011.