PMID- 27325245
OWN - NLM
STAT- MEDLINE
DCOM- 20170517
LR  - 20180614
IS  - 1479-6805 (Electronic)
IS  - 0022-0795 (Linking)
VI  - 230
IP  - 2
DP  - 2016 Aug
TI  - Calcium reduces vitamin D and glucocorticoid receptors in the visceral fat of 
      obese male rats.
PG  - 263-74
LID - 10.1530/JOE-16-0041 [doi]
AB  - Rats overfed during lactation show higher visceral adipose tissue (VAT) mass and 
      metabolic dysfunctions at adulthood. As both vitamin D and glucocorticoids change 
      adipogenesis, parameters related to metabolism and action of these hormones in 
      the adipocyte can be altered in rats raised in small litters (SL). We also 
      studied the antiobesity effects of high calcium diet since it decreases visceral 
      fat in obesity models. On postnatal day (PN) 3, litter size was adjusted to 
      3pups/dam (SL) to induce overfeeding. Control litters (NL) remained with 
      10pups/dam until weaning. From PN120 to PN180, half of the SL rats were fed 
      standard chow (SL) and the other half was fed a calcium-supplemented chow (SL-Ca, 
      10g CaCO3/kg). Both SL groups were heavier and hyperphagic when compared with the 
      NL group; however, SL-Ca rats ate less than SL. SL-Ca rats had decreased VAT mass 
      and adipocyte size, associated with lower hypothalamic NPY content, VAT fat acid 
      synthase content and leptinemia. At PN120, SL rats had increased plasma 25(OH)D3, 
      Cyp27b1 mRNA and glucocorticoid receptor (GR-alpha) in the VAT, but lower vitamin D 
      receptor (Vdr) mRNA. At PN180, Cyp27b1 and GR-alpha remained higher, while Vdr 
      normalized in SL rats. SL-Ca rats had normal VAT Cyp27b1 and GR-alpha, but lower Vdr 
      Thus, higher body mass and glucocorticoid receptors in the VAT of SL rats are 
      normalized by calcium-enriched diet, and Vdr expression in this tissue is 
      reduced, suggesting a possible role of glucocorticoids and vitamin D in calcium 
      action in the adipocyte.
CI  - (c) 2016 Society for Endocrinology.
FAU - Conceicao, E P S
AU  - Conceicao EP
AD  - Laboratory of Endocrine PhysiologyDepartment of Physiological Sciences, Roberto 
      Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Moura, E G
AU  - Moura EG
AD  - Laboratory of Endocrine PhysiologyDepartment of Physiological Sciences, Roberto 
      Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Manhaes, A C
AU  - Manhaes AC
AD  - Laboratory of NeurophysiologyDepartment of Physiological Sciences, Roberto 
      Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Carvalho, J C
AU  - Carvalho JC
AD  - Laboratory of Endocrine PhysiologyDepartment of Physiological Sciences, Roberto 
      Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Nobre, J L
AU  - Nobre JL
AD  - Laboratory of Endocrine PhysiologyDepartment of Physiological Sciences, Roberto 
      Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Oliveira, E
AU  - Oliveira E
AD  - Laboratory of Endocrine PhysiologyDepartment of Physiological Sciences, Roberto 
      Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Lisboa, P C
AU  - Lisboa PC
AD  - Laboratory of Endocrine PhysiologyDepartment of Physiological Sciences, Roberto 
      Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de 
      Janeiro, Brazil pclisboa@uerj.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160620
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Receptors, Glucocorticoid)
RN  - 1406-16-2 (Vitamin D)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/pharmacology/*therapeutic use
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Intra-Abdominal Fat/*drug effects/metabolism
MH  - Male
MH  - Obesity/etiology/metabolism/*prevention & control
MH  - Rats, Wistar
MH  - Receptors, Glucocorticoid/*metabolism
MH  - Vitamin D/*metabolism
OTO - NOTNLM
OT  - NPY
OT  - calcium supplementation
OT  - corticosterone
OT  - overnutrition
OT  - vitamin D3
EDAT- 2016/06/22 06:00
MHDA- 2017/05/18 06:00
CRDT- 2016/06/22 06:00
PHST- 2016/05/26 00:00 [received]
PHST- 2016/06/20 00:00 [accepted]
PHST- 2016/06/22 06:00 [entrez]
PHST- 2016/06/22 06:00 [pubmed]
PHST- 2017/05/18 06:00 [medline]
AID - JOE-16-0041 [pii]
AID - 10.1530/JOE-16-0041 [doi]
PST - ppublish
SO  - J Endocrinol. 2016 Aug;230(2):263-74. doi: 10.1530/JOE-16-0041. Epub 2016 Jun 20.