PMID- 27325934
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160621
LR  - 20201001
IS  - 1759-1104 (Print)
IS  - 1759-1104 (Electronic)
IS  - 1759-1104 (Linking)
VI  - 2
IP  - 1
DP  - 2010
TI  - The non-thyroidal illness syndrome in acute coronary syndrome is associated with 
      increased cardiac morbidity and mortality.
PG  - 11-4
LID - 10.1136/ha.2009.001503 [doi]
AB  - INTRODUCTION: The non-thyroidal illness syndrome (NTIS) or the sick euthyroid 
      syndrome refers to abnormal changes in circulating thyroid hormones due to 
      systemic illnesses. Thyroid hormones are pivotal in the regulation of normal 
      cardiac functions. However, the effects of the NTIS on the heart in acute 
      coronary syndrome (ACS) are still unclear. METHODS: A 6-month prospective cohort 
      study involving 85 patients admitted with ACS was carried out. TSH, FT4 and FT3 
      were assessed on days 1, 5 and 42. Antithyroid peroxidase antibodies, 
      antithyroglobulin antibodies, fasting blood sugar, HbA1c and fasting serum lipid 
      were obtained on admission. Mortality, functional status (Killip and New York 
      Heart Association Classifications), arrhythmias and readmission rate were 
      recorded. RESULTS: The prevalence of NTIS was 53%. It was seen in 48% of unstable 
      angina (UA), 54% of non-ST elevation myocardial infarction (NSTEMI) and 56% of ST 
      elevation myocardial infarction (STEMI) patients. NTIS is associated with 
      cardiovascular mortality, all-cause mortality, severe heart failure and a higher 
      readmission rate. The levels of FT3 correlate with severity of myocardial damage 
      as measured by CK and Troponin T. Lower TSH was seen in the non-survivors and in 
      those with ventricular arrhythmias. The most common presentation of NTIS was low 
      FT3 (43.5%), followed by low TSH (12.9%) and FT4 (4.7%). None of the predisposing 
      factors analysed were associated with the development of NTIS. CONCLUSIONS: NTIS 
      in patients with ACS is associated with increased cardiovascular mortality and 
      morbidity, and affects UA, NSTEMI and STEMI equally.
FAU - Adawiyah, J
AU  - Adawiyah J
AD  - Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Norasyikin, A W
AU  - Norasyikin AW
AD  - Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Mat, N H
AU  - Mat NH
AD  - Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Shamsul, A S
AU  - Shamsul AS
AD  - Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), 
      Cheras, Kuala Lumpur, Malaysia; Department of Community Health, Universiti 
      Kebangsaan Malaysia Medical Centre (UKMMC), Cheras, Kuala Lumpur, Malaysia.
FAU - Azmi, K Nor
AU  - Azmi KN
AD  - Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), 
      Cheras, Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20100706
PL  - England
TA  - Heart Asia
JT  - Heart Asia
JID - 101542742
PMC - PMC4898515
OTO - NOTNLM
OT  - Non-thyroidal illness syndrome (NTIS)
OT  - acute coronary syndrome
COIS- Competing interests: None.
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2010/07/06
CRDT- 2016/06/22 06:00
PHST- 2009/12/27 00:00 [accepted]
PHST- 2016/06/22 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2010/07/06 00:00 [pmc-release]
AID - heartasia-2009-001503 [pii]
AID - 10.1136/ha.2009.001503 [doi]
PST - epublish
SO  - Heart Asia. 2010 Jul 6;2(1):11-4. doi: 10.1136/ha.2009.001503. eCollection 2010.