PMID- 27325943 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160621 LR - 20201001 IS - 1759-1104 (Print) IS - 1759-1104 (Electronic) IS - 1759-1104 (Linking) VI - 2 IP - 1 DP - 2010 TI - Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy. PG - 52-5 LID - 10.1136/ha.2010.002006 [doi] AB - BACKGROUND: Cardiac involvement is a recognised complication in female carriers of Duchenne muscular dystrophy (DMD). Since segmental or global left ventricle (LV) wall motion abnormalities in DMD carriers can arise even without apparent muscle weakness, it is difficult to differentiate cardiac involvement of a DMD carrier from other heart diseases in a non-invasive manner. Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) enables assessment of regional wall motion abnormality and myocardial damage with high spatial resolution. OBJECTIVE: To assess the utility of CMR for detection of myocardial damage in female carriers of DMD. METHODS AND RESULTS: Gadolinium-enhanced CMR was performed in seven female DMD carriers. Physical examination, electrocardiography, chest radiograph, measurements of total creatinine kinase and brain natriuretic peptide levels, and two-dimensional echocardiography were also performed. Four (57%) of the seven carriers had LGE, and LGE was frequently observed at the subepicardial layer in the inferolateral segment. Two carriers had a focal LGE at the LV inferolateral wall without LV dilation or wall motion abnormalities. CONCLUSION: CMR findings of DMD carriers were characterised by subepicardial LGE, which was localised at inferolateral segments. CMR may be a useful modality for detecting cardiac involvement in DMD carriers. FAU - Iwase, Takashi AU - Iwase T AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Takao, Shoichiro AU - Takao S AD - Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Akaike, Masashi AU - Akaike M AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Adachi, Katsuhito AU - Adachi K AD - Department of Internal Medicine and Neurology, Tokushima National Hospital, Tokushima, Japan. FAU - Sumitomo-Ueda, Yuka AU - Sumitomo-Ueda Y AD - Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Yagi, Shusuke AU - Yagi S AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Niki, Toshiyuki AU - Niki T AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Kusunose, Kenya AU - Kusunose K AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Tomita, Noriko AU - Tomita N AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Hirata, Yoichiro AU - Hirata Y AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Yamaguchi, Koji AU - Yamaguchi K AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Koshiba, Kunihiko AU - Koshiba K AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Taketani, Yoshio AU - Taketani Y AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Yamada, Hirotsugu AU - Yamada H AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Soeki, Takeshi AU - Soeki T AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Wakatsuki, Tetsuzo AU - Wakatsuki T AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Aihara, Ken-Ichi AU - Aihara K AD - Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Harada, Masafumi AU - Harada M AD - Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Nishitani, Hiromu AU - Nishitani H AD - Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. FAU - Sata, Masataka AU - Sata M AD - Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. LA - eng PT - Journal Article DEP - 20100729 PL - England TA - Heart Asia JT - Heart Asia JID - 101542742 PMC - PMC4898527 OTO - NOTNLM OT - MRI OT - cardiomyopathies OT - gadolinium OT - muscular dystrophies COIS- Competing interests: None. EDAT- 2010/01/01 00:00 MHDA- 2010/01/01 00:01 PMCR- 2010/07/29 CRDT- 2016/06/22 06:00 PHST- 2010/06/08 00:00 [accepted] PHST- 2016/06/22 06:00 [entrez] PHST- 2010/01/01 00:00 [pubmed] PHST- 2010/01/01 00:01 [medline] PHST- 2010/07/29 00:00 [pmc-release] AID - heartasia-2010-002006 [pii] AID - 10.1136/ha.2010.002006 [doi] PST - epublish SO - Heart Asia. 2010 Jul 29;2(1):52-5. doi: 10.1136/ha.2010.002006. eCollection 2010.