PMID- 27326005
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160621
LR  - 20220309
IS  - 1759-1104 (Print)
IS  - 1759-1104 (Electronic)
IS  - 1759-1104 (Linking)
VI  - 3
IP  - 1
DP  - 2011
TI  - Sex differences in hospital mortality following acute myocardial infarction in 
      China: findings from a study of 45 852 patients in the COMMIT/CCS-2 study.
PG  - 104-10
LID - 10.1136/heartasia-2011-010003 [doi]
AB  - OBJECTIVE: To assess the sex difference in hospital mortality following ST 
      elevation myocardial infarction (STEMI) in China. DESIGN: Observational study of 
      patients enrolled into a large trial, adjusting for age, presenting 
      characteristics and hospital treatments using logistic regression. SETTINGS: 1250 
      hospitals in China during 1999-2005. PATIENTS: 42 683 STEMI patients, including 
      31 309 men and 11 374 women. INTERVENTION: In the original trial, all patients 
      received 162 mg of aspirin plus 75 mg of clopidogrel daily or matching placebo 
      and metoprolol (15 mg intravenous then 200 mg oral daily) or matching placebo. 
      All other aspects of patients' treatments were at the discretion of responsible 
      doctors. MAJOR OUTCOMES: Hospital mortality from any cause during the scheduled 
      trial treatment period (ie, up to 4 weeks in hospital). RESULTS: Overall, 8% of 
      the patients died in hospital, with the crude hospital mortality being twice as 
      high in women as in men (12.6% vs 6.3%). After adjusting for age, the sex 
      difference in hospital mortality attenuated but remained highly significant (OR 
      1.54; 95% CI 1.43 to 1.66). Further adjustment for other baseline characteristics 
      and for the treatments given in hospital had little effect on the sex difference 
      in hospital mortality (OR 1.50, 95% CI 1.38 to 1.62). The difference in hospital 
      mortality was greater at a younger age, with the adjusted ORs being 2.14, 1.70, 
      1.48 and 1.18, respectively, for ages <55, 55-64, 65-74 and >/=75 years (p=0.0001 
      for trend). CONCLUSION: Compared with men of the same age, women had 
      approximately a 50% higher mortality following hospital admission for STEMI, with 
      a particularly higher excess risk at age <55 years.
FAU - Chen, Yiping
AU  - Chen Y
AD  - Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield 
      Department of Clinical Medicine, University of Oxford, Oxford, UK; China Oxford 
      Centre for International Health Research, Fuwai Hospital, Chinese Academy of 
      Medical Sciences, Beijing, PR China.
FAU - Jiang, Lixin
AU  - Jiang L
AD  - China Oxford Centre for International Health Research, Fuwai Hospital, Chinese 
      Academy of Medical Sciences, Beijing, PR China.
FAU - Smith, Margaret
AU  - Smith M
AD  - Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield 
      Department of Clinical Medicine, University of Oxford, Oxford, UK.
FAU - Pan, Hongchao
AU  - Pan H
AD  - Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield 
      Department of Clinical Medicine, University of Oxford, Oxford, UK.
FAU - Collins, Rory
AU  - Collins R
AD  - Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield 
      Department of Clinical Medicine, University of Oxford, Oxford, UK.
FAU - Peto, Richard
AU  - Peto R
AD  - Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield 
      Department of Clinical Medicine, University of Oxford, Oxford, UK.
FAU - Chen, Zhengming
AU  - Chen Z
AD  - Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield 
      Department of Clinical Medicine, University of Oxford, Oxford, UK; China Oxford 
      Centre for International Health Research, Fuwai Hospital, Chinese Academy of 
      Medical Sciences, Beijing, PR China.
CN  - COMMIT/CCS-2 collaborative group
LA  - eng
PT  - Journal Article
DEP - 20110101
PL  - England
TA  - Heart Asia
JT  - Heart Asia
JID - 101542742
PMC - PMC4898572
OTO - NOTNLM
OT  - Coronary artery disease
OT  - STEMI
OT  - gender
COIS- Competing interests: None.
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
PMCR- 2011/01/01
CRDT- 2016/06/22 06:00
PHST- 2011/08/16 00:00 [accepted]
PHST- 2016/06/22 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - heartasia-2011-010003 [pii]
AID - 10.1136/heartasia-2011-010003 [doi]
PST - epublish
SO  - Heart Asia. 2011 Jan 1;3(1):104-10. doi: 10.1136/heartasia-2011-010003. 
      eCollection 2011.