PMID- 27326017
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160621
LR  - 20201001
IS  - 1759-1104 (Print)
IS  - 1759-1104 (Electronic)
IS  - 1759-1104 (Linking)
VI  - 4
IP  - 1
DP  - 2012
TI  - Antistreptokinase antibodies and the response to thrombolysis with streptokinase 
      in patients with acute ST elevation myocardial infarction.
PG  - 7-10
LID - 10.1136/heartasia-2012-010094 [doi]
AB  - BACKGROUND AND OBJECTIVE: A large number of patients with ST elevation myocardial 
      infarction (STEMI) continue to receive streptokinase (SK) in the developing 
      countries. High levels of antistreptokinase (ASK) antibodies can result in 
      failure of thrombolysis. This study was conducted to assess the presence of ASK 
      antibodies in the general population and its effect on the outcome of 
      thrombolysis with SK. DESIGN: Prospective observational study. SETTING: A 
      tertiary care medical institute in Vellore, India. PATIENTS: 148 patients 
      presenting with STEMI undergoing thrombolysis with SK were recruited. MAIN 
      OUTCOME MEASURES: The response to SK was assessed by reperfusion markers in the 
      patients and they were categorised as good responders, probable responders and 
      non-responders. Those who responded to SK and probable responders were considered 
      to have benefited from thrombolysis. RESULTS: 60 patients (40%) had ASK antibody 
      titres higher than the median. In patients with a window period <6 h, 73% of 
      patients who benefited from thrombolysis had low ASK titres while 100% of the 
      patients who did not benefit had high ASK titres (p=0.001). Similarly, in 
      patients with a window period >6 h, 89% of patients who benefited from 
      thrombolysis had low ASTK titres while 54% of those who did not benefit had high 
      ASK titres (p=0.002). CONCLUSIONS: ASK antibodies are present in significant 
      titres in a large proportion of patients in developing countries, which leads to 
      failure of thrombolysis in such patients. In endemic areas with high endemic 
      streptococcal infection, alternative agents should be used for thrombolysis in 
      STEMI.
FAU - Subhendu, M S K
AU  - Subhendu MS
AD  - Department of Cardiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - George, Oommen K
AU  - George OK
AD  - Department of Cardiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - Prakash, John A Jude
AU  - Prakash JA
AD  - Department of Microbiology, Serology division, Christian Medical College, 
      Vellore, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
DEP - 20120101
PL  - England
TA  - Heart Asia
JT  - Heart Asia
JID - 101542742
PMC - PMC4898615
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - antistreptokinase
OT  - coronary intervention (PCI)
OT  - coronary stenting
OT  - device closure
OT  - myocardial ischaemia and infarction (IHD)
OT  - streptokinase
OT  - thrombolysis
OT  - valvular disease
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/01/01
CRDT- 2016/06/22 06:00
PHST- 2012/01/19 00:00 [accepted]
PHST- 2016/06/22 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - heartasia-2012-010094 [pii]
AID - 10.1136/heartasia-2012-010094 [doi]
PST - epublish
SO  - Heart Asia. 2012 Jan 1;4(1):7-10. doi: 10.1136/heartasia-2012-010094. eCollection 
      2012.