PMID- 27328642
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Jun 22
TI  - Serum Uric Acid Levels were Dynamically Coupled with Hemoglobin A1c in the 
      Development of Type 2 Diabetes.
PG  - 28549
LID - 10.1038/srep28549 [doi]
LID - 28549
AB  - The aim of the study was to decipher the relationship between serum uric acid 
      (SUA) and glycated hemoglobin A1c (HbA1c) or fasting plasma glucose (FPG) in both 
      type 2 diabetes mellitus (T2DM) patients and normal subjects. A total of 2,250 
      unrelated T2DM patients and 4,420 Han Chinese subjects from a physical 
      examination population were recruited for this study. In T2DM patients SUA levels 
      were negatively correlated with HbA1c (rs = -0.109, P = 0.000) and 2 h plasma 
      glucose levels (rs = -0.178, P = 0.000). In the physical examination population, 
      SUA levels were inversely correlated with HbA1c (rs = -0.175, P = 0.000) and FPG 
      (rs = -0.131, P = 0.009) in T2DM patients but positively correlated with HbA1c 
      (rs = 0.040, P = 0.012) and FPG (rs = 0.084, P = 0.000) in normal-glucose 
      subjects. Multivariate analyses showed that HbA1c was significantly negatively 
      associated with HUA both in T2DM patients (OR = 0.872, 95% CI: 0.790~0.963) and 
      in the physical examination T2DM patients (OR = 0.722, 95% CI: 0.539~0.968). 
      Genetic association studies in T2DM patients showed that alleles of two 
      glucose-uric acid transporter genes, ABCG2 and SLC2A9 were significantly 
      associated with SUA levels (P < 0.05). SUA level is inversely correlated with 
      HbA1c in T2DM patients but positively correlated with HbA1c in normal-glucose 
      subjects. The reverse transporting of uric acid and glucose in renal tubules 
      might be accounted for these associations.
FAU - Wei, Fengjiang
AU  - Wei F
AD  - Center of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, 
      Tianjin, 300070, P.R. China.
FAU - Chang, Baocheng
AU  - Chang B
AD  - Metabolic Diseases Hospital, Tianjin Medical University, Tianjin, 300070, P.R. 
      China.
FAU - Yang, Xilin
AU  - Yang X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, 22 Qixiangtai Road, Tianjin, 300070, P.R. China.
FAU - Wang, Yaogang
AU  - Wang Y
AD  - School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 
      300070, P.R. China.
FAU - Chen, Liming
AU  - Chen L
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, 22 Qixiangtai Road, Tianjin, 300070, P.R. China.
FAU - Li, Wei-Dong
AU  - Li WD
AD  - Center of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, 
      Tianjin, 300070, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160622
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (ABCG2 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 2)
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transport Proteins, Facilitative)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (SLC2A9 protein, human)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/*etiology/genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Glucose Transport Proteins, Facilitative/genetics
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Proteins/genetics
MH  - Risk Factors
MH  - Uric Acid/*blood
PMC - PMC4916504
EDAT- 2016/06/23 06:00
MHDA- 2018/05/08 06:00
PMCR- 2016/06/22
CRDT- 2016/06/23 06:00
PHST- 2016/01/08 00:00 [received]
PHST- 2016/06/03 00:00 [accepted]
PHST- 2016/06/23 06:00 [entrez]
PHST- 2016/06/23 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2016/06/22 00:00 [pmc-release]
AID - srep28549 [pii]
AID - 10.1038/srep28549 [doi]
PST - epublish
SO  - Sci Rep. 2016 Jun 22;6:28549. doi: 10.1038/srep28549.