PMID- 27329511 OWN - NLM STAT- MEDLINE DCOM- 20170414 LR - 20170727 IS - 1468-3083 (Electronic) IS - 0926-9959 (Linking) VI - 30 IP - 11 DP - 2016 Nov TI - Survival of classic and biological systemic drugs in psoriasis: results of the BIOBADADERM registry and critical analysis. PG - 1942-1950 LID - 10.1111/jdv.13682 [doi] AB - BACKGROUND: Few reported studies compare drug survival in moderate-to-severe psoriasis vulgaris. OBJECTIVES: To describe and compare drug survival of systemic drugs, including biologic agents (infliximab, etanercept, adalimumab and ustekinumab) and classical drugs (acitretin, ciclosporin and methotrexate) in moderate-to-severe psoriasis. METHODS: This was a multicenter, prospective, cohort study of patients receiving systemic therapies between 2008 and 2013 in 12 hospitals in Spain. Baseline data and drug discontinuation were collected. Drug survival is presented using Kaplan-Meier survival curves. We compared adjusted risk ratios of serious adverse events (AEs) with results of survival analysis for AEs. RESULTS: A total of 1956 patients were included for analysis (1240 exposed to biologics during follow-up and 1076 to classic therapies). Median follow-up time was 3.3 years (0.0-5.1 years). There were 2209 discontinuations out of 3640 therapy cycles started. The main reason for discontinuation was lack of efficacy (36.4%) and remission (27.2%). Biologics showed a higher drug survival than classics and the pattern of survival results for all outcomes (positive or negative) were very similar. Adjusted risk ratios of serious AEs did not agree with results of survival analysis. LIMITATIONS: A limitation is that this is an observational study with potential selection bias. CONCLUSION: Survival as a proxy measure of drug safety in psoriasis is inadequate. CI - (c) 2016 European Academy of Dermatology and Venereology. FAU - Davila-Seijo, P AU - Davila-Seijo P AD - Research Unit, Fundacion Academia Espanola de Dermatologia y Venereologia, Madrid, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Universitario La Princesa, Madrid, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Universitario Reina Sofia, Cordoba, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Universitario Virgen de la Victoria, Malaga, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Infanta Leonor, Madrid, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital General Universitario de Alicante, Alicante, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain. pauladavilaseijo@gmail.com. AD - Department of Dermatology and Venereology, Umea University Hospital, Umea, Sweden. pauladavilaseijo@gmail.com. FAU - Dauden, E AU - Dauden E AD - Department of Dermatology, Hospital Universitario La Princesa, Madrid, Spain. FAU - Carretero, G AU - Carretero G AD - Department of Dermatology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain. FAU - Ferrandiz, C AU - Ferrandiz C AD - Department of Dermatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain. FAU - Vanaclocha, F AU - Vanaclocha F AD - Department of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain. FAU - Gomez-Garcia, F-J AU - Gomez-Garcia FJ AD - Department of Dermatology, Hospital Universitario Reina Sofia, Cordoba, Spain. FAU - Herrera-Ceballos, E AU - Herrera-Ceballos E AD - Department of Dermatology, Hospital Universitario Virgen de la Victoria, Malaga, Spain. FAU - De la Cueva-Dobao, P AU - De la Cueva-Dobao P AD - Department of Dermatology, Hospital Infanta Leonor, Madrid, Spain. FAU - Belinchon, I AU - Belinchon I AD - Department of Dermatology, Hospital General Universitario de Alicante, Alicante, Spain. FAU - Sanchez-Carazo, J-L AU - Sanchez-Carazo JL AD - Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain. FAU - Alsina, M AU - Alsina M AD - Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Lopez-Estebaranz, J-L AU - Lopez-Estebaranz JL AD - Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain. FAU - Ferran, M AU - Ferran M AD - Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. FAU - Torrado, R AU - Torrado R AD - Department of Dermatology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain. FAU - Carrascosa, J-M AU - Carrascosa JM AD - Department of Dermatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain. FAU - Llamas, M AU - Llamas M AD - Department of Dermatology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain. FAU - Rivera, R AU - Rivera R AD - Department of Dermatology, Hospital Universitario Reina Sofia, Cordoba, Spain. FAU - Jimenez-Puya, R AU - Jimenez-Puya R AD - Department of Dermatology, Hospital Universitario Virgen de la Victoria, Malaga, Spain. FAU - Garcia-Doval, I AU - Garcia-Doval I AD - Research Unit, Fundacion Academia Espanola de Dermatologia y Venereologia, Madrid, Spain. AD - Department of Dermatology, Complexo Hospitalario Universitario de Vigo, Vigo, Spain. CN - BIOBADADERM Study Group LA - eng PT - Journal Article PT - Multicenter Study DEP - 20160622 PL - England TA - J Eur Acad Dermatol Venereol JT - Journal of the European Academy of Dermatology and Venereology : JEADV JID - 9216037 RN - 0 (Dermatologic Agents) SB - IM MH - Dermatologic Agents/*therapeutic use MH - Humans MH - Prospective Studies MH - Psoriasis/*drug therapy MH - *Registries FIR - Zafrilla, Beatriz Perez IR - Zafrilla BP FIR - Munoz-Santos, Carlos IR - Munoz-Santos C FIR - Mendiola-Fernandez, Victoria IR - Mendiola-Fernandez V FIR - Roldan, Cristina Sanchez IR - Roldan CS FIR - Ruiz-Genao, Diana IR - Ruiz-Genao D FIR - Echeverria, Begona IR - Echeverria B FIR - Mejias, Sagrario Galiano IR - Mejias SG EDAT- 2016/10/25 06:00 MHDA- 2017/04/15 06:00 CRDT- 2016/06/23 06:00 PHST- 2015/12/23 00:00 [received] PHST- 2016/02/22 00:00 [accepted] PHST- 2016/10/25 06:00 [pubmed] PHST- 2017/04/15 06:00 [medline] PHST- 2016/06/23 06:00 [entrez] AID - 10.1111/jdv.13682 [doi] PST - ppublish SO - J Eur Acad Dermatol Venereol. 2016 Nov;30(11):1942-1950. doi: 10.1111/jdv.13682. Epub 2016 Jun 22.