PMID- 27329608
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20181202
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 70
IP  - 11
DP  - 2016 Nov
TI  - The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced 
      diarrhea in people with abdominal and pelvic cancer: a systematic review and 
      meta-analysis.
PG  - 1246-1253
LID - 10.1038/ejcn.2016.102 [doi]
AB  - A systematic review and meta-analysis were designed to evaluate the efficacy and 
      safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in 
      people with abdominal and pelvic cancer. We searched the Cochrane Library, 
      PubMed, EMBASE and Web of Science up to November 2015. We also hand searched the 
      citation lists of included studies and previously identified systematic reviews 
      to identify further relevant trials. Odds ratio (OR) was used to compare 
      efficacy, and the pooled OR was estimated using a random effects model; 
      heterogeneity was assessed with Cochran's Q and the Higgins' I(2)-test. Two 
      reviewers assessed trial quality and extracted data independently. Analysis and 
      bias for each included study were performed using Review Manager 5.2. Nine 
      randomized and placebo-controlled studies (N=1265 participants) were included for 
      assessing efficacy, of which seven were about radiotherapy and two about 
      chemotherapy. Probiotic groups were compared with control groups with respect to 
      the the incidence of diarrhea, OR=0.47 (95% confidence interval 0.28-0.76; 
      P=0.002). Eleven studies, including 1612 people (873 consuming probiotics and 739 
      not consuming probiotics), were used for the analysis of safety of probiotics. Of 
      the 11 studies, seven studies had no adverse events (AEs) caused by probiotics, 
      whereas four studies reported varying degrees of AEs in their treatment. 
      Probiotics may have a beneficial effect in prevention of 
      chemoradiotherapy-induced diarrhea generally, especially for Grade⩾2 diarrhea. 
      Probiotics may rarely cause AEs.
FAU - Wang, Y-H
AU  - Wang YH
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      China.
FAU - Yao, N
AU  - Yao N
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      China.
FAU - Wei, K-K
AU  - Wei KK
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      China.
FAU - Jiang, L
AU  - Jiang L
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      China.
FAU - Hanif, S
AU  - Hanif S
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
FAU - Wang, Z-X
AU  - Wang ZX
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
AD  - Evidence Based Medical Centre of Lanzhou University, Lanzhou, China.
FAU - Pei, C-X
AU  - Pei CX
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
AD  - Evidence Based Medical Centre of Lanzhou University, Lanzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160622
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
SB  - IM
MH  - Abdominal Neoplasms/drug therapy/radiotherapy
MH  - Diarrhea/prevention & control
MH  - Humans
MH  - Inflammatory Bowel Diseases/*prevention & control
MH  - Pelvic Neoplasms/drug therapy/radiotherapy
MH  - *Probiotics
MH  - Radiation Injuries/*prevention & control
MH  - Randomized Controlled Trials as Topic
MH  - Safety
EDAT- 2016/11/03 06:00
MHDA- 2018/01/05 06:00
CRDT- 2016/06/23 06:00
PHST- 2015/12/17 00:00 [received]
PHST- 2016/05/05 00:00 [revised]
PHST- 2016/05/14 00:00 [accepted]
PHST- 2016/11/03 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
PHST- 2016/06/23 06:00 [entrez]
AID - ejcn2016102 [pii]
AID - 10.1038/ejcn.2016.102 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2016 Nov;70(11):1246-1253. doi: 10.1038/ejcn.2016.102. Epub 2016 
      Jun 22.