PMID- 27332742
OWN - NLM
STAT- MEDLINE
DCOM- 20170803
LR  - 20170817
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 219
DP  - 2016 Sep 15
TI  - The impact of exercise on ventricular arrhythmias in adults with tetralogy of 
      Fallot.
PG  - 218-24
LID - S0167-5273(16)31020-8 [pii]
LID - 10.1016/j.ijcard.2016.06.011 [doi]
AB  - BACKGROUND: Sudden death of presumed arrhythmic etiology is the leading cause of 
      mortality in adults with tetralogy of Fallot. OBJECTIVES: To assess the impact of 
      exercise on ventricular arrhythmias in adults with tetralogy of Fallot. METHODS: 
      Adults with repaired tetralogy of Fallot were randomized in a 2:1 ratio to an 
      open-label trial of standard care versus 12weeks of supervised combined 
      aerobic/resistance training with continuous Holter monitoring. Proportion of 
      premature ventricular complexes (PVC) and runs of non-sustained ventricular 
      tachycardia (NSVT) were assessed by mixed and Poisson regression models with 
      generalized estimating equations for repeated measures. RESULTS: A total of 152 
      Holters were performed in 17 patients, median age 35 (interquartile range [IQR] 
      28, 42) years, 65% male, 13 of whom were randomized to exercise training. 
      Baseline characteristics were similar between groups. Exercise training resulted 
      in significant increases in peak oxygen uptake (11+/-19%, p=0.028), metabolic 
      equivalents (11+/-18%, p=0.027), and exercise duration (8+/-10%, p=0.009) compared to 
      no changes in controls. Frequent (>/=30 per hour) PVCs were present in 46% of 
      patients, couplets in 62%, and 3 to 7 beat runs of NSVT in 31%. The median 
      proportion of PVCs was 1.93 per thousand (IQR 0.41, 5.89) at baseline and 1.45 per thousand (IQR 0.08, 
      2.76) during the initial exercise session (p=0.722), and remained stable over 
      time (ss coefficient=-0.031, p=0.408). Runs of NSVT decreased significantly over 
      time (ss coefficient=-0.032, p=0.018). CONCLUSION: In adults with repaired 
      tetralogy of Fallot, exercise training is safe, improves exercise capacity, and 
      appears to confer a beneficial effect on ventricular arrhythmias.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Avila, Pablo
AU  - Avila P
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada; Department of Cardiology, Instituto de Investigacion Sanitaria, 
      Hospital Gregorio Maranon, Universidad Complutense, Madrid, Spain.
FAU - Marcotte, Francois
AU  - Marcotte F
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Dore, Annie
AU  - Dore A
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Mercier, Lise-Andree
AU  - Mercier LA
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Shohoudi, Azadeh
AU  - Shohoudi A
AD  - Montreal Health Innovations Coordinating Center, Universite de Montreal, 
      Montreal, Canada.
FAU - Mongeon, Francois-Pierre
AU  - Mongeon FP
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Mondesert, Blandine
AU  - Mondesert B
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Proietti, Anna
AU  - Proietti A
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Ibrahim, Reda
AU  - Ibrahim R
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Asgar, Anita
AU  - Asgar A
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Poirier, Nancy
AU  - Poirier N
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada.
FAU - Khairy, Paul
AU  - Khairy P
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Canada; Montreal Health Innovations Coordinating Center, Universite de 
      Montreal, Montreal, Canada. Electronic address: paul.khairy@umontreal.ca.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160614
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Outpatient Clinics, Hospital/trends
MH  - Resistance Training/*methods/trends
MH  - Tachycardia, Ventricular/*physiopathology/*rehabilitation
MH  - Tetralogy of Fallot/*physiopathology/*rehabilitation
OTO - NOTNLM
OT  - Exercise
OT  - Tetralogy of Fallot
OT  - Training
OT  - Ventricular tachycardia
EDAT- 2016/06/23 06:00
MHDA- 2017/08/05 06:00
CRDT- 2016/06/23 06:00
PHST- 2016/04/29 00:00 [received]
PHST- 2016/06/12 00:00 [accepted]
PHST- 2016/06/23 06:00 [entrez]
PHST- 2016/06/23 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
AID - S0167-5273(16)31020-8 [pii]
AID - 10.1016/j.ijcard.2016.06.011 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Sep 15;219:218-24. doi: 10.1016/j.ijcard.2016.06.011. Epub 
      2016 Jun 14.