PMID- 27333462
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20180611
IS  - 1755-148X (Electronic)
IS  - 1755-1471 (Linking)
VI  - 29
IP  - 5
DP  - 2016 Sep
TI  - Simple chronic colitis model using hypopigmented mice with a Hermansky-Pudlak 
      syndrome 5 gene mutation.
PG  - 578-82
LID - 10.1111/pcmr.12504 [doi]
AB  - Pigmentation in mammals is important for protection of skin and eyes from 
      ultraviolet radiation. Dysregulation of pigmentation is often associated with 
      other conditions that are not directly linked to pigmentation. Here, we isolated 
      spontaneously occurring hypopigmented mice that occasionally experienced severe 
      diarrhea during lactation. Treatment of these mice with dextran sulfate sodium 
      salt, a conventional method to induce acute colitis, caused chronic diarrhea with 
      granulomatous colitis. Gene mapping and sequencing revealed that the mice had a 
      nonsense mutation in the Hermansky-Pudlak syndrome (Hps)5 gene. As some HPS 
      patients can develop granulomatous colitis, the simple induction of chronic 
      colitis in spontaneously mutated Hps5-deficient mice may become an invaluable 
      model for exploring treatment options in patients with HPS as well as other 
      patients with inflammatory bowel disease.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Itoh, Yumi
AU  - Itoh Y
AD  - Cell Signaling and Metabolic Disease, National Institute of Biomedical 
      Innovation, Ibaraki, Osaka, Japan. yumiitoh0308@gmail.com.
FAU - Nagaoka, Yasuo
AU  - Nagaoka Y
AD  - Department of Life Science and Biotechnology, Kansai University, Suita, Osaka, 
      Japan.
FAU - Katakura, Yoshio
AU  - Katakura Y
AD  - Department of Life Science and Biotechnology, Kansai University, Suita, Osaka, 
      Japan.
FAU - Kawahara, Hidehisa
AU  - Kawahara H
AD  - Department of Life Science and Biotechnology, Kansai University, Suita, Osaka, 
      Japan.
FAU - Takemori, Hiroshi
AU  - Takemori H
AD  - Cell Signaling and Metabolic Disease, National Institute of Biomedical 
      Innovation, Ibaraki, Osaka, Japan. mukuharu22@yahoo.co.jp.
LA  - eng
SI  - GENBANK/LC151021
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160808
PL  - England
TA  - Pigment Cell Melanoma Res
JT  - Pigment cell & melanoma research
JID - 101318927
RN  - 0 (Carrier Proteins)
RN  - 0 (Codon, Nonsense)
RN  - 0 (HPS5 protein, human)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/*genetics
MH  - Chronic Disease
MH  - *Codon, Nonsense
MH  - Colitis/chemically induced/*genetics/pathology
MH  - Dextran Sulfate/toxicity
MH  - *Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Hypopigmentation/*genetics/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
OTO - NOTNLM
OT  - Hermansky-Pudlak syndrome
OT  - chronic
OT  - colitis
OT  - mouse model
OT  - pigmentation
EDAT- 2016/06/23 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/06/23 06:00
PHST- 2016/03/12 00:00 [received]
PHST- 2016/06/16 00:00 [accepted]
PHST- 2016/06/23 06:00 [entrez]
PHST- 2016/06/23 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1111/pcmr.12504 [doi]
PST - ppublish
SO  - Pigment Cell Melanoma Res. 2016 Sep;29(5):578-82. doi: 10.1111/pcmr.12504. Epub 
      2016 Aug 8.