PMID- 27333744
OWN - NLM
STAT- MEDLINE
DCOM- 20160721
LR  - 20160623
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 74
IP  - 4
DP  - 2016 Apr
TI  - [The neurovascular unit in health and ischemic stroke].
PG  - 583-8
AB  - The neurovascular unit (NVU), a minimal unit to exert neurological functions, is 
      composed of neurons, astrocytes, endothelial cells, pericytes, and extracellular 
      matrix proteins forming basal membranes. The cell components interact with one 
      another and function cooperatively under both physiological and pathological 
      conditions. Pericytes and astrocytes participate crucially in the formation and 
      maintenance of the blood-brain barrier (BBB), the tight junction formed by 
      endothelial cells, and regulate cerebral blood flow in response to neurological 
      activities. The BBB actively regulate molecular import and export. The concept of 
      the NVU is also useful for understanding pathogenesis and exploring therapeutic 
      targets in various CNS disorders. In this review, recent research advances 
      regarding the NVU and its components in health and ischemic stroke are 
      summarized.
FAU - Ago, Tetsuro
AU  - Ago T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Astrocytes/*physiology
MH  - Blood-Brain Barrier/*physiology
MH  - Cell Communication/physiology
MH  - Cell Movement
MH  - Cerebrovascular Circulation/physiology
MH  - Endothelial Cells/*physiology
MH  - Extracellular Matrix/physiology
MH  - Humans
MH  - Molecular Targeted Therapy
MH  - Pericytes/*physiology
MH  - Stroke/*etiology/pathology/physiopathology/therapy
MH  - Tight Junctions/physiology
EDAT- 2016/06/24 06:00
MHDA- 2016/07/22 06:00
CRDT- 2016/06/24 06:00
PHST- 2016/06/24 06:00 [entrez]
PHST- 2016/06/24 06:00 [pubmed]
PHST- 2016/07/22 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2016 Apr;74(4):583-8.