PMID- 2733388 OWN - NLM STAT- MEDLINE DCOM- 19890727 LR - 20190510 IS - 0146-4760 (Print) IS - 0146-4760 (Linking) VI - 13 IP - 2 DP - 1989 Mar-Apr TI - An apparent fatal overdose of terodiline. PG - 110-2 AB - The results of a forensic toxicological investigation on a young man with an unknown cause of death are reported here. Analysis revealed the presence of a possibly fatal level of terodiline in blood and urine. No other drugs were detected. Terodiline was detected by thin-layer and gas-liquid chromatography and identified by gas chromatography/mass spectrometry. Quantification was carried out by a mass fragmentographic procedure using the m/z 100 from terodiline for selective ion monitoring (SIM). The blood and urine concentrations were found to be greater than 10 mg/L, whereas therapeutic concentrations in serum are usually not more than 1 mg/L. Support and confirmation of the laboratory results was provided at the subsequent inquest. It was revealed that the deceased had died from the inhalation of vomit due to an oral overdose of terodiline. To the best of our knowledge this is the first reported death due to fatal poisoning with terodiline in the United Kingdom. FAU - Cattini, R A AU - Cattini RA AD - Department of Chemical Pathology, London Hospital Medical College, United Kingdom. FAU - Makin, H L AU - Makin HL FAU - Trafford, D J AU - Trafford DJ FAU - Vanezis, P AU - Vanezis P LA - eng PT - Case Reports PT - Journal Article PL - England TA - J Anal Toxicol JT - Journal of analytical toxicology JID - 7705085 RN - 0 (Butylamines) RN - 0 (Parasympatholytics) RN - 70KG06964W (terodiline) SB - IM EIN - J Anal Toxicol 1990 May-Jun;14(3):194 MH - Adult MH - Butylamines/blood/*poisoning/urine MH - Humans MH - Male MH - Parasympatholytics/blood/*poisoning/urine EDAT- 1989/03/01 00:00 MHDA- 1989/03/01 00:01 CRDT- 1989/03/01 00:00 PHST- 1989/03/01 00:00 [pubmed] PHST- 1989/03/01 00:01 [medline] PHST- 1989/03/01 00:00 [entrez] AID - 10.1093/jat/13.2.110 [doi] PST - ppublish SO - J Anal Toxicol. 1989 Mar-Apr;13(2):110-2. doi: 10.1093/jat/13.2.110.