PMID- 27334641
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160727
LR  - 20200930
IS  - 2383-7837 (Print)
IS  - 2383-7845 (Electronic)
IS  - 2383-7837 (Linking)
VI  - 50
IP  - 4
DP  - 2016 Jul
TI  - Significance of Parafibromin Expression in Laryngeal Squamous Cell Carcinomas.
PG  - 264-9
LID - 10.4132/jptm.2016.04.24 [doi]
AB  - BACKGROUND: Parafibromin is a product of the tumor suppressor gene that has been 
      studied as a potential indicator of tumor aggressiveness in the parathyroid, 
      breast, colorectum, and stomach. However, the clinical significance and potential 
      function of parafibromin expression in head and neck squamous cell carcinomas 
      remain largely unknown. The aim of this study was to evaluate the expression of 
      parafibromin in laryngeal squamous cell carcinoma (LSCC) and to verify its 
      potential as a biomarker of tumor behavior. METHODS: Parafibromin expression was 
      evaluated in 30 cases of LSCC using immunohistochemistry. The correlations 
      between parafibromin expression and clinicopathologic parameters were 
      investigated. RESULTS: Parafibromin expression was positive in 15 cases (50%) and 
      negative in 15 cases (50%). Tumor size and T stage showed a statistically 
      significant inverse relationship with parafibromin expression (p=.028 and p<.001, 
      respectively). Parafibromin expression was not associated with age, sex, lymph 
      node metastasis, tumor differentiation, or tumor location. There was no 
      statistically significant relationship between parafibromin expression and 
      progression-free survival in the patients (p>.05). CONCLUSIONS: Our results 
      indicate that the downregulation or loss of parafibromin expression can be 
      employed as a novel marker of tumor progression or aggressiveness in LSCC.
FAU - Cho, Inju
AU  - Cho I
AD  - Department of Pathology, Chosun University School of Medicine, Gwangju, Korea.
FAU - Lee, Mija
AU  - Lee M
AD  - Department of Pathology, Chosun University School of Medicine, Gwangju, Korea.
FAU - Lim, Sharon
AU  - Lim S
AD  - Department of Pathology, Chosun University School of Medicine, Gwangju, Korea.
FAU - Hong, Ran
AU  - Hong R
AD  - Department of Pathology, Chosun University School of Medicine, Gwangju, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160623
PL  - Korea (South)
TA  - J Pathol Transl Med
JT  - Journal of pathology and translational medicine
JID - 101650151
PMC - PMC4963974
OTO - NOTNLM
OT  - Carcinoma, squamous cell
OT  - Epithelial-mesenchymal transition
OT  - Parafibromin
COIS- Conflicts of Interest No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2016/06/24 06:00
MHDA- 2016/06/24 06:01
PMCR- 2016/07/01
CRDT- 2016/06/24 06:00
PHST- 2015/12/30 00:00 [received]
PHST- 2016/04/15 00:00 [revised]
PHST- 2016/04/24 00:00 [accepted]
PHST- 2016/06/24 06:00 [entrez]
PHST- 2016/06/24 06:00 [pubmed]
PHST- 2016/06/24 06:01 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - jptm.2016.04.24 [pii]
AID - jptm-2016-04-24 [pii]
AID - 10.4132/jptm.2016.04.24 [doi]
PST - ppublish
SO  - J Pathol Transl Med. 2016 Jul;50(4):264-9. doi: 10.4132/jptm.2016.04.24. Epub 
      2016 Jun 23.