PMID- 27336232
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20240325
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 150
DP  - 2016 Oct
TI  - Lactation history, serum concentrations of persistent organic pollutants, and 
      maternal risk of diabetes.
PG  - 282-288
LID - S0013-9351(16)30258-4 [pii]
LID - 10.1016/j.envres.2016.06.023 [doi]
AB  - OBJECTIVE: Lactation may help curb diabetes risk and is also known as an 
      excretion route for some environmental pollutants. We evaluated associations of 
      lifetime lactation history with serum concentrations of persistent organic 
      pollutants (POPs) in the National Health and Nutrition Examination Survey 
      1999-2006, and examined whether potentially diabetogenic POPs account for 
      associations between lactation and diabetes. RESEARCH DESIGN AND METHODS: Among 
      4479 parous women, breastfeeding history was defined as the number of children 
      breastfed >/=1 month. Diabetes was identified by self-report or hemoglobin A1c 
      >6.5%. Twenty-four POPs were measured in serum among subsamples of 668 to 1073 
      participants. RESULTS: Compared with women without lactation history, odds ratios 
      (95% confidence intervals) of having diabetes among those with 1-2 and >/=3 
      lactation periods were 0.83(0.61, 1.13) and 0.63(0.44, 0.91; P trend=0.03). 
      Lifetime lactation history was inversely associated with serum concentrations of 
      17 out of the 24 organochlorine pesticides, polychlorinated biphenyl congeners 
      (PCBs), and perfluoroalkyl substances (Ptrend<0.05). Comparing the >/=3 lactations 
      group with women without a lactation history, the relative reduction of POPs 
      ranged from 12% (PCB-196) to 30% (oxychlordane). The inverse association between 
      lactation and diabetes was slightly attenuated after adjustment for POPs. 
      Age-stratified analyses showed that the inverse association between lactation 
      periods and serum POP concentrations was observed primarily among participants 
      <60 years, whereas age did not significantly modify the association between 
      lactation history and diabetes prevalence. CONCLUSION: Crudely-classified 
      lifetime lactation history was inversely associated with concurrent serum POP 
      concentrations and diabetes prevalence. Prospective studies are needed to clarify 
      how lactation could complement diabetes prevention through decreasing the POP 
      body burdens.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Zong, Geng
AU  - Zong G
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 
      USA.
FAU - Grandjean, Philippe
AU  - Grandjean P
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, USA; Institute of Public Health, University of Southern Denmark, 
      Odense, Denmark.
FAU - Wang, Xiaobin
AU  - Wang X
AD  - Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA; 
      Center on the Early Life Origins of Disease, Department of Population, Family and 
      Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Johns 
      Hopkins School of Medicine, Baltimore, MD, USA.
FAU - Sun, Qi
AU  - Sun Q
AD  - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 
      USA; Channing Division of Network Medicine, Department of Medicine, Brigham and 
      Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: 
      qisun@hsph.harvard.edu.
LA  - eng
GR  - R01 ES021372/ES/NIEHS NIH HHS/United States
GR  - R03 ES022790/ES/NIEHS NIH HHS/United States
GR  - R00 HL098459/HL/NHLBI NIH HHS/United States
GR  - R01 ES022981/ES/NIEHS NIH HHS/United States
GR  - R01 ES021447/ES/NIEHS NIH HHS/United States
GR  - R01 ES021477/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160620
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus/*epidemiology/etiology
MH  - Environmental Exposure
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - *Lactation
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Prevalence
MH  - Risk
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC5003647
MID - NIHMS797318
OTO - NOTNLM
OT  - Diabetes
OT  - Lactation
OT  - Persistent organic pollutant
COIS- declaration: All authors declare that they received no support from any 
      organization for the submitted work; no financial relationships with any 
      organizations that might have an interest in the submitted work in the previous 
      three years, and no other relationships or activities that could appear to have 
      influenced the submitted work.
EDAT- 2016/06/24 06:00
MHDA- 2017/05/02 06:00
PMCR- 2017/10/01
CRDT- 2016/06/24 06:00
PHST- 2016/03/11 00:00 [received]
PHST- 2016/06/14 00:00 [revised]
PHST- 2016/06/14 00:00 [accepted]
PHST- 2016/06/24 06:00 [entrez]
PHST- 2016/06/24 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - S0013-9351(16)30258-4 [pii]
AID - 10.1016/j.envres.2016.06.023 [doi]
PST - ppublish
SO  - Environ Res. 2016 Oct;150:282-288. doi: 10.1016/j.envres.2016.06.023. Epub 2016 
      Jun 20.