PMID- 2733656
OWN - NLM
STAT- MEDLINE
DCOM- 19890721
LR  - 20190919
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 11
IP  - 2
DP  - 1989 Mar-Apr
TI  - The disposition of 14C-trimethyltin in the pregnant rat and fetus.
PG  - 185-91
AB  - Trimethyltin (TMT) is a potent neurotoxicant. For unknown reasons, age at 
      exposure to TMT may dramatically influence the severity of TMT-induced 
      neuropathology. We have demonstrated previously that radiolabel derived from 
      [14C]-TMT given to pregnant dams on gestational day (GD) 17 is found in fetal 
      brain and blood. The present study was designed to determine the distribution of 
      radiolabel derived from [14C]-TMT to brain and other tissue in fetuses from dams 
      dosed on either GD 12 or 17 with 7.0 mg/kg TMT chloride. Radioactivity in GD 12 
      and GD 17 maternal whole blood peaked 1 hour after IP treatment. Whole blood 
      elimination half-lives were 12-15 days. Peak radiolabel concentrations in GD 12 
      maternal and fetal brain were only 11-30% of those from GD 17 animals, however, 
      peak fetal brain concentrations of radiolabel were not different from their 
      respective maternal brain concentrations. Radiolabel concentrations in liver, 
      kidney, and adrenal of GD 17 dams were higher than those in corresponding GD 12 
      tissues. Combined urinary and fecal elimination of radiolabel for two weeks after 
      dosing accounted for 31 and 22% of the GD 12 and 17 doses, respectively. It 
      appears that gestational age influences the distribution and elimination of TMT 
      in the rat.
FAU - Lipscomb, J C
AU  - Lipscomb JC
AD  - Division of Reproductive and Developmental Toxicology, National Center for 
      Toxicological Research, Jefferson, AR 72079.
FAU - Paule, M G
AU  - Paule MG
FAU - Slikker, W Jr
AU  - Slikker W Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Trialkyltin Compounds)
RN  - 0 (Trimethyltin Compounds)
RN  - 1631-73-8 (trimethyltin)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Carbon Radioisotopes
MH  - Female
MH  - Fetus/*metabolism
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Pregnancy, Animal/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
MH  - Trialkyltin Compounds/*pharmacokinetics
MH  - Trimethyltin Compounds/*pharmacokinetics
EDAT- 1989/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/03/01 00:00
PHST- 1989/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/03/01 00:00 [entrez]
AID - 0892-0362(89)90057-3 [pii]
AID - 10.1016/0892-0362(89)90057-3 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1989 Mar-Apr;11(2):185-91. doi: 
      10.1016/0892-0362(89)90057-3.