PMID- 27337949
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160819
LR  - 20200930
IS  - 1976-8710 (Print)
IS  - 2005-0720 (Electronic)
IS  - 1976-8710 (Linking)
VI  - 9
IP  - 3
DP  - 2016 Sep
TI  - The Expression and Relationship of CD68-Tumor-Associated Macrophages and 
      Microvascular Density With the Prognosis of Patients With Laryngeal Squamous Cell 
      Carcinoma.
PG  - 270-7
LID - 10.21053/ceo.2015.01305 [doi]
AB  - OBJECTIVES: We sought to identify the expression of CD68-tumor-associated 
      macrophages (TAMs) and CD34-microvascular density (MVD) in laryngeal squamous 
      cell carcinoma (LSCC), to study the relationship with clinical pathological 
      parameters and to determine whether their expression is predictive of disease. 
      METHODS: Pathologically confirmed 45 LSCC tissue and 20 peritumoral non-tumor 
      tissue were examined. Immunohistochemical studies were used to detect the 
      expression of CD68-TAMs and CD34-MVD. RESULTS: The positive expression rate of 
      CD68 in LSCC tissue was 82% (37/45), which was higher than the 10% (2/20) 
      expression rate of the peritumoral tissue (P<0.05). The CD34-MVD positive 
      expression rate in the LSCC tissue was 26.5+/-6.4, which obviously higher than 
      12.2+/-4.0 expression rate of the peritumoral tissue (P<0.05). The positive 
      expression rates of both CD68 and CD34-MVD were higher in the lymph node 
      metastasis (LNM) positive group than in the LNM negative group. The expression of 
      CD68 had positive correlation with CD34-MVD. The 5-year disease-free survival 
      rate in the group with the low CD68 expression was significantly higher than that 
      in the group with high CD68 expression (76% vs. 42%, respectively). CONCLUSION: 
      The high expression of CD68-TAMs in LSCC and its positive correlation with 
      CD34-MVD illustrates that both play an important role in promoting the metastasis 
      and angiogenesis of this cancer. Their expression was also positively correlated 
      with the prognoses of these patients, suggesting that they could be used as 
      important prognostic markers for LSCC.
FAU - Sun, Shujun
AU  - Sun S
AD  - Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, 
      China.
FAU - Pan, Xinliang
AU  - Pan X
AD  - Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, 
      China.
FAU - Zhao, Limin
AU  - Zhao L
AD  - Department of Otorhinolaryngology, The Affiliated Hospital of Weifang Medical 
      University, Weifang, China.
FAU - Zhou, Jianming
AU  - Zhou J
AD  - Department of Otorhinolaryngology, The Affiliated Hospital of Weifang Medical 
      University, Weifang, China.
FAU - Wang, Hongzeng
AU  - Wang H
AD  - Department of Otorhinolaryngology, The Affiliated Hospital of Weifang Medical 
      University, Weifang, China.
FAU - Sun, Yonghong
AU  - Sun Y
AD  - Department of Pathology, The Affiliated Hospital of Weifang Medical University, 
      Weifang, China.
LA  - eng
PT  - Journal Article
DEP - 20160625
PL  - Korea (South)
TA  - Clin Exp Otorhinolaryngol
JT  - Clinical and experimental otorhinolaryngology
JID - 101474010
PMC - PMC4996099
OTO - NOTNLM
OT  - CD
OT  - Laryngeal Neoplasms
OT  - Microvascular Density
OT  - Tumor-Associated Macrophages
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/06/25 06:00
MHDA- 2016/06/25 06:01
PMCR- 2016/09/01
CRDT- 2016/06/25 06:00
PHST- 2015/08/21 00:00 [received]
PHST- 2015/12/05 00:00 [revised]
PHST- 2016/01/12 00:00 [accepted]
PHST- 2016/06/25 06:00 [entrez]
PHST- 2016/06/25 06:00 [pubmed]
PHST- 2016/06/25 06:01 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - ceo.2015.01305 [pii]
AID - ceo-2015-01305 [pii]
AID - 10.21053/ceo.2015.01305 [doi]
PST - ppublish
SO  - Clin Exp Otorhinolaryngol. 2016 Sep;9(3):270-7. doi: 10.21053/ceo.2015.01305. 
      Epub 2016 Jun 25.