PMID- 27338057
OWN - NLM
STAT- MEDLINE
DCOM- 20170721
LR  - 20180317
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 20
IP  - 11
DP  - 2016 Jun
TI  - The coexistence of eosinophilic esophagitis with allergic rhinitis.
PG  - 2315-23
LID - 10923 [pii]
AB  - OBJECTIVE: Eosinophilic esophagitis (EoE) is diagnosed with the presence of 
      characteristic esophageal symptoms and eosinophilic infiltration of the 
      esophageal mucosa after other causes of eosinophilia are excluded. EoE has been 
      reported to co-occur with some allergic diseases. In this study, we evaluated the 
      co-existence of EoE in Ear-Nose-Throat (ENT) outpatient clinic patients with 
      allergic rhinitis (AR). PATIENTS AND METHODS: The study group consists of 67 AR 
      patients (AR group) and the control group (CG) was formed with 53 cases with 
      dyspepsia symptoms. Symptoms of AR and CG groups were compared in terms of 
      endoscopic and histological findings. Moreover, in AR group, accompanying 
      symptoms, immunoglobulin E (IgE), skin prick test (SPT) positivity, Helicobacter 
      pylori (H. pylori) presence, endoscopic findings and biopsy results were compared 
      between patients with EoE and those without. RESULTS: Seven of the cases with AR 
      were diagnosed with EoE. Reflux symptoms were more common in patients with EoE 
      (71.4%). The presence of H. pylori was similar between groups. Blood IgE levels 
      were significantly higher among EoE patients compared to those without EoE (p = 
      0.003). SPT positivity was present in the 85.7% of patients with EoE and 50% of 
      the patients without EoE (p = 0.113). Allergens were more likely to be mites 
      Dermatophagoides farinae and Dermatophagoides pteronyssinus in patients with EoE 
      (p = 0.042 and p = 0.034 respectively). CONCLUSIONS: The most common symptom 
      among patients with EoE is reflux. In AR patients with EoE, serum IgE levels were 
      higher compared to those without EoE. In AR patients with reflux symptoms, high 
      serum IgE levels, and especially in patients whose tests are positive for allergy 
      to mites, referral to a gastroenterologist for EoE evaluation may be recommended.
FAU - Soylu, A
AU  - Soylu A
AD  - Department of Gastroenterology, Department of Otolaryngology, Department of 
      Internal Medicine, Department of Pathology; Bakirkoy Dr. Sadi Konuk Education and 
      Research Hospital, Istanbul, Turkey. asoylu2@hotmail.com.
FAU - Altintas, A
AU  - Altintas A
FAU - Cakmak, S
AU  - Cakmak S
FAU - Poturoglu, S
AU  - Poturoglu S
FAU - Kaya, H
AU  - Kaya H
FAU - Sevindir, I
AU  - Sevindir I
FAU - Okuturlar, Y
AU  - Okuturlar Y
FAU - Sever, N
AU  - Sever N
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - *Eosinophilic Esophagitis
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - *Rhinitis, Allergic
MH  - Skin Tests
EDAT- 2016/06/25 06:00
MHDA- 2017/07/22 06:00
CRDT- 2016/06/25 06:00
PHST- 2016/06/25 06:00 [entrez]
PHST- 2016/06/25 06:00 [pubmed]
PHST- 2017/07/22 06:00 [medline]
AID - 10923 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2016 Jun;20(11):2315-23.