PMID- 27338296 OWN - NLM STAT- MEDLINE DCOM- 20171117 LR - 20181113 IS - 1469-8978 (Electronic) IS - 0033-2917 (Print) IS - 0033-2917 (Linking) VI - 46 IP - 12 DP - 2016 Sep TI - Risperidone-induced topological alterations of anatomical brain network in first-episode drug-naive schizophrenia patients: a longitudinal diffusion tensor imaging study. PG - 2549-60 LID - 10.1017/S0033291716001380 [doi] AB - BACKGROUND: It remains unclear whether the topological deficits of the white matter network documented in cross-sectional studies of chronic schizophrenia patients are due to chronic illness or to other factors such as antipsychotic treatment effects. To answer this question, we evaluated the white matter network in medication-naive first-episode schizophrenia patients (FESP) before and after a course of treatment. METHOD: We performed a longitudinal diffusion tensor imaging study in 42 drug-naive FESP at baseline and then after 8 weeks of risperidone monotherapy, and compared them with 38 healthy volunteers. Graph theory was utilized to calculate the topological characteristics of brain anatomical network. Patients' clinical state was evaluated using the Positive and Negative Syndrome Scale (PANSS) before and after treatment. RESULTS: Pretreatment, patients had relatively intact overall topological organizations, and deficient nodal topological properties primarily in prefrontal gyrus and limbic system components such as the bilateral anterior and posterior cingulate. Treatment with risperidone normalized topological parameters in the limbic system, and the enhancement positively correlated with the reduction in PANSS-positive symptoms. Prefrontal topological impairments persisted following treatment and negative symptoms did not improve. CONCLUSIONS: During the early phase of antipsychotic medication treatment there are region-specific alterations in white matter topological measures. Limbic white matter topological dysfunction improves with positive symptom reduction. Prefrontal deficits and negative symptoms are unresponsive to medication intervention, and prefrontal deficits are potential trait biomarkers and targets for negative symptom treatment development. FAU - Hu, M AU - Hu M AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. FAU - Zong, X AU - Zong X AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. FAU - Zheng, J AU - Zheng J AD - Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,People's Republic of China. FAU - Mann, J J AU - Mann JJ AD - Division of Molecular Imaging and Neuropathology,New York State Psychiatric Institute and Departments of Psychiatry and Radiology,Columbia University,1051 Riverside Drive,Box 42,New York,NY 10032,USA. FAU - Li, Z AU - Li Z AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. FAU - Pantazatos, S P AU - Pantazatos SP AD - Division of Molecular Imaging and Neuropathology,New York State Psychiatric Institute and Departments of Psychiatry,Columbia University,New York, NY 10032,USA. FAU - Li, Y AU - Li Y AD - Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,People's Republic of China. FAU - Liao, Y AU - Liao Y AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. FAU - He, Y AU - He Y AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. FAU - Zhou, J AU - Zhou J AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. FAU - Sang, D AU - Sang D AD - Department of Radiology,Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,People's Republic of China. FAU - Zhao, H AU - Zhao H AD - Department of Radiology,Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,People's Republic of China. FAU - Tang, J AU - Tang J AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. FAU - Chen, H AU - Chen H AD - Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,People's Republic of China. FAU - Lv, L AU - Lv L AD - Department of Psychiatry,Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,People's Republic of China. FAU - Chen, X AU - Chen X AD - Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China. LA - eng GR - K01 MH108721/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20160624 PL - England TA - Psychol Med JT - Psychological medicine JID - 1254142 RN - 0 (Antipsychotic Agents) RN - L6UH7ZF8HC (Risperidone) SB - IM MH - Adolescent MH - Adult MH - Antipsychotic Agents/administration & dosage/*pharmacology MH - Diffusion Tensor Imaging MH - Follow-Up Studies MH - Humans MH - *Limbic System/diagnostic imaging/drug effects/pathology/physiopathology MH - Longitudinal Studies MH - *Nerve Net/diagnostic imaging/drug effects/pathology/physiopathology MH - *Prefrontal Cortex/diagnostic imaging/drug effects/pathology/physiopathology MH - Risperidone/administration & dosage/*pharmacology MH - *Schizophrenia/diagnostic imaging/drug therapy/pathology/physiopathology MH - *White Matter/diagnostic imaging/drug effects/pathology/physiopathology MH - Young Adult PMC - PMC5242555 MID - NIHMS841594 OTO - NOTNLM OT - First-episode schizophrenia OT - longitudinal studies OT - networks OT - schizophrenia OT - topology OT - white matter COIS- Declaration of Interest J.J.M. received royalties for commercial use of the Columbia Suicide Severity Rating Scale (C-SSRS) from the Research Foundation for Mental Hygiene. EDAT- 2016/06/25 06:00 MHDA- 2017/11/29 06:00 PMCR- 2017/09/01 CRDT- 2016/06/25 06:00 PHST- 2016/06/25 06:00 [entrez] PHST- 2016/06/25 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] PHST- 2017/09/01 00:00 [pmc-release] AID - S0033291716001380 [pii] AID - 10.1017/S0033291716001380 [doi] PST - ppublish SO - Psychol Med. 2016 Sep;46(12):2549-60. doi: 10.1017/S0033291716001380. Epub 2016 Jun 24.