PMID- 27338301
OWN - NLM
STAT- MEDLINE
DCOM- 20170508
LR  - 20210806
IS  - 1096-0309 (Electronic)
IS  - 0003-2697 (Linking)
VI  - 510
DP  - 2016 Oct 1
TI  - RNA-MethylPred: A high-accuracy predictor to identify N6-methyladenosine in RNA.
PG  - 72-75
LID - S0003-2697(16)30139-7 [pii]
LID - 10.1016/j.ab.2016.06.012 [doi]
AB  - N6-methyladenosine (m(6)A) is present ubiquitously in the RNA of living organisms 
      from Escherichia coli to humans. Nonetheless, the exact molecular mechanism of 
      this modification remains unclear. The experimental identification of m(6)A 
      modification is time-consuming and expensive; therefore, bioinformatics tools 
      with high accuracy represent desirable alternatives for the large-scale, rapid 
      identification of N6-methyladenosine sites. In this study, RNA-MethylPred, a new 
      bioinformatics model, was developed by incorporating bi-profile Bayes, 
      dinucleotide composition, and k nearest neighbor (KNN) scores for three feature 
      extractions. RNA-MethylPred yielded a Matthew's correlation coefficient (MCC) of 
      0.53 in a jackknife test, which was 0.24 higher than that of iRNA-Methyl and 0.13 
      higher than that of pRNAm-PC. The obvious improvements demonstrated that 
      RNA-MethylPred might be a powerful and complementary tool for further 
      experimental investigation of N6-methyladenosine modification.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Jia, Cang-Zhi
AU  - Jia CZ
AD  - Department of Mathematics, Dalian Maritime University, Dalian 116026, China. 
      Electronic address: cangzhijia@dlmu.edu.cn.
FAU - Zhang, Jia-Jia
AU  - Zhang JJ
AD  - Department of Mathematics, Dalian Maritime University, Dalian 116026, China.
FAU - Gu, Wei-Zhen
AU  - Gu WZ
AD  - Department of Mathematics, Dalian Maritime University, Dalian 116026, China.
LA  - eng
PT  - Journal Article
DEP - 20160620
PL  - United States
TA  - Anal Biochem
JT  - Analytical biochemistry
JID - 0370535
RN  - 63231-63-0 (RNA)
RN  - CLE6G00625 (N-methyladenosine)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/*analogs & derivatives/genetics
MH  - RNA/*genetics
MH  - Sequence Analysis, RNA/*methods
MH  - *Software
OTO - NOTNLM
OT  - Bi-profile Bayes
OT  - Dinucleotide frequency
OT  - RNA methylation
OT  - Support vector machine
OT  - k nearest neighbor
EDAT- 2016/06/25 06:00
MHDA- 2017/05/10 06:00
CRDT- 2016/06/25 06:00
PHST- 2016/03/11 00:00 [received]
PHST- 2016/06/07 00:00 [revised]
PHST- 2016/06/08 00:00 [accepted]
PHST- 2016/06/25 06:00 [entrez]
PHST- 2016/06/25 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
AID - S0003-2697(16)30139-7 [pii]
AID - 10.1016/j.ab.2016.06.012 [doi]
PST - ppublish
SO  - Anal Biochem. 2016 Oct 1;510:72-75. doi: 10.1016/j.ab.2016.06.012. Epub 2016 Jun 
      20.