PMID- 27340510
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20181113
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2016
DP  - 2016
TI  - Influence of Insulin Resistance and TNF-alpha on the Inflammatory Process, Oxidative 
      Stress, and Disease Activity in Patients with Rheumatoid Arthritis.
PG  - 8962763
LID - 10.1155/2016/8962763 [doi]
LID - 8962763
AB  - The aim of this study was to evaluate the involvement of TNF-alpha and insulin 
      resistance (IR) in the inflammatory process, oxidative stress, and disease 
      activity in patients with rheumatoid arthritis (RA). This cross-sectional study 
      included 270 subjects (control group, n = 97) and RA patients (n = 173). RA 
      patients were divided into four groups: the first group without IR and not using 
      antitumor necrosis factor-alpha (TNF-) (G1, IR- TNF-); the second group without IR 
      and using anti-TNF-alpha (G2, IR- TNF+); the third group with IR and not using 
      anti-TNF-alpha (G3, IR+ TNF-); and the fourth group with IR and using anti-TNF-alpha (G4, 
      IR+ TNF+). G3 and G4 had higher (p < 0.05) advanced oxidation protein products 
      (AOPPs) and oxidative stress index (OSI) compared to G1. G4 group presented 
      higher (p < 0.05) AOPPs and OSI than G2. TRAP was significantly lower in G3 
      compared to G1. Plasma TNF-alpha levels were significantly higher in G4 and G2 
      compared to G1 (p < 0.0001) and G3 (p < 0.0001 and p < 0.01, resp.). The presence 
      of insulin resistance was robustly associated with both oxidative stress and 
      TNF-alpha levels. More studies are warranted to verify if IR can be involved in 
      therapeutic failure with TNF-alpha inhibitors. This trial is registered with 
      Brazilian Clinical Trials Registry Register number RBR-2jvj92.
FAU - Costa, Neide Tomimura
AU  - Costa NT
AUID- ORCID: 0000-0001-6624-2043
AD  - Department of Rheumatology, University of Londrina (UEL), Londrina, PR, Brazil.
FAU - Veiga Iriyoda, Tatiana Mayumi
AU  - Veiga Iriyoda TM
AUID- ORCID: 0000-0002-0801-3098
AD  - Department of Rheumatology, University of Londrina (UEL), Londrina, PR, Brazil.
FAU - Kallaur, Ana Paula
AU  - Kallaur AP
AUID- ORCID: 0000-0001-9563-971X
AD  - Department of Clinical Analysis, University North of Parana (UNOPAR), Londrina, 
      PR, Brazil.
FAU - Delongui, Francieli
AU  - Delongui F
AD  - Department of Clinical Pathology, University of Londrina, Robert Koch Avenue No. 
      60 Bairro Cervejaria, Londrina 86038-440, PR, Brazil.
FAU - Alfieri, Daniela Frizon
AU  - Alfieri DF
AD  - Department of Clinical Pathology, University of Londrina, Robert Koch Avenue No. 
      60 Bairro Cervejaria, Londrina 86038-440, PR, Brazil.
FAU - Lozovoy, Marcell Alysson Batisti
AU  - Lozovoy MA
AD  - Department of Clinical Pathology, University of Londrina, Robert Koch Avenue No. 
      60 Bairro Cervejaria, Londrina 86038-440, PR, Brazil.
FAU - Amin, Ricardo Braga
AU  - Amin RB
AD  - Department of Rheumatology, University of Londrina (UEL), Londrina, PR, Brazil.
FAU - Delfino, Vinicius Daher Alvares
AU  - Delfino VD
AUID- ORCID: 0000-0002-5443-9348
AD  - Department of Internal Medicine, University of Londrina, Londrina, PR, Brazil.
FAU - Dichi, Isaias
AU  - Dichi I
AD  - Department of Internal Medicine, University of Londrina, Londrina, PR, Brazil.
FAU - Simao, Andrea Name Colado
AU  - Simao AN
AD  - Department of Clinical Pathology, University of Londrina, Robert Koch Avenue No. 
      60 Bairro Cervejaria, Londrina 86038-440, PR, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160531
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Advanced Oxidation Protein Products)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Advanced Oxidation Protein Products/blood
MH  - Aged
MH  - Antirheumatic Agents/therapeutic use
MH  - Arthritis, Rheumatoid/*blood/diagnosis/drug therapy/immunology
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/antagonists & inhibitors/*blood/immunology
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - *Oxidative Stress/drug effects
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/*blood/immunology
PMC - PMC4906209
EDAT- 2016/06/25 06:00
MHDA- 2017/03/14 06:00
PMCR- 2016/05/31
CRDT- 2016/06/25 06:00
PHST- 2015/12/08 00:00 [received]
PHST- 2016/04/19 00:00 [accepted]
PHST- 2016/06/25 06:00 [entrez]
PHST- 2016/06/25 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2016/05/31 00:00 [pmc-release]
AID - 10.1155/2016/8962763 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2016;2016:8962763. doi: 10.1155/2016/8962763. Epub 2016 May 
      31.