PMID- 27340932
OWN - NLM
STAT- MEDLINE
DCOM- 20170130
LR  - 20191210
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 89
IP  - 1065
DP  - 2016 Sep
TI  - Contrast-enhanced ultrasonography of cervical carcinoma: perfusion pattern and 
      relationship with tumour angiogenesis.
PG  - 20150887
LID - 10.1259/bjr.20150887 [doi]
LID - 20150887
AB  - OBJECTIVE: This study aimed to investigate the use of contrast-enhanced 
      ultrasonography (CEUS) and time-intensity curves to assess angiogenesis in 
      cervical cancer. METHODS: 60 patients who were scheduled to undergo radical 
      surgery for biopsy-proven cervical cancers underwent CEUS. Surgical tissue 
      sections from 32 patients who did not receive neoadjuvant chemotherapy were 
      analyzed with CD34 staining to estimate intratumoral microvessel density (MVD). 
      CEUS images were analyzed for maximum intensity (IMAX), rise time (RT), time to 
      peak (TTP) and mean transit time. RESULTS: Cervical lesions had a higher IMAX and 
      shorter RT and TTP (p < 0.001) than reference regions. There was a linear 
      association between the IMAX of the cervical lesion and the mean intratumoral MVD 
      (r = 0.624, p < 0.001). There were no significant differences in CEUS variables 
      according to histological type, grade and stage. CONCLUSION: Quantitative CEUS 
      variables have potential use for monitoring perfusion changes in tumours after 
      non-surgical therapy for advanced cervical cancer. ADVANCES IN KNOWLEDGE: The 
      article demonstrates the capability and value of quantitative CEUS as a 
      non-invasive strategy for detecting the perfusion and angiogenic status of 
      cervical cancer. Quantitative CEUS variables have potential use for monitoring 
      tumour response to non-surgical therapy.
FAU - Zheng, Wei
AU  - Zheng W
AD  - 1 Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer 
      Medicine, Guangzhou, China.
FAU - Xiong, Yong-Hong
AU  - Xiong YH
AD  - 1 Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer 
      Medicine, Guangzhou, China.
FAU - Han, Jing
AU  - Han J
AD  - 1 Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer 
      Medicine, Guangzhou, China.
FAU - Guo, Zhi-Xing
AU  - Guo ZX
AD  - 1 Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer 
      Medicine, Guangzhou, China.
FAU - Li, Yu-Hong
AU  - Li YH
AD  - 2 Department of Ultrasound, The First Affiliated Hospital of Nanhua University, 
      Hengyang, China.
FAU - Li, An-Hua
AU  - Li AH
AD  - 1 Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer 
      Medicine, Guangzhou, China.
FAU - Pei, Xiao-Qing
AU  - Pei XQ
AD  - 1 Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer 
      Medicine, Guangzhou, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20160624
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Microbubbles
MH  - Microvessels/diagnostic imaging/pathology
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*diagnostic imaging
MH  - Phospholipids
MH  - Sulfur Hexafluoride
MH  - Ultrasonography/methods
MH  - Uterine Cervical Neoplasms/*blood supply/diagnostic imaging/pathology
PMC - PMC5124911
EDAT- 2016/06/25 06:00
MHDA- 2017/01/31 06:00
PMCR- 2017/09/01
CRDT- 2016/06/25 06:00
PHST- 2016/06/25 06:00 [entrez]
PHST- 2016/06/25 06:00 [pubmed]
PHST- 2017/01/31 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 10.1259/bjr.20150887 [doi]
PST - ppublish
SO  - Br J Radiol. 2016 Sep;89(1065):20150887. doi: 10.1259/bjr.20150887. Epub 2016 Jun 
      24.