PMID- 27341324
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20181202
IS  - 2152-0895 (Electronic)
IS  - 1539-8412 (Print)
IS  - 1539-8412 (Linking)
VI  - 40
IP  - 4
DP  - 2017 Oct/Dec
TI  - Changes in Function After a 6-Month Walking Intervention in Patients With 
      Intermittent Claudication Who Are Obese or Nonobese.
PG  - 190-196
LID - 10.1519/JPT.0000000000000096 [doi]
AB  - BACKGROUND AND PURPOSE: Both obesity and peripheral artery disease (PAD) limit 
      function and may work additively to reduce mobility. The purpose of this study 
      was to compare the effects of a 6-month, center-based walking program on mobility 
      function between adults who are weight-stable obese and nonobese with PAD. 
      METHODS: This is a secondary data analysis of 2 combined studies taken from 
      previous work. Fifty-three adults with PAD and intermittent claudication 
      participated in 6 months of treadmill training or standard of care. Patients were 
      divided into 4 groups for analyses: exercise nonobese (Ex), exercise obese (ExO), 
      standard-of-care nonobese (SC), and standard-of-care obese (SCO). Mobility was 
      assessed by a standardized treadmill test to measure claudication onset time 
      (COT) and peak walking time (PWT) as well as the distance walked during a 
      6-minute walk distance (6MWD) test. RESULTS: There was a significant (P < .001) 
      interaction (intervention x obesity) effect on 6MWD, wherein both exercise groups 
      improved (Ex = 7%, ExO = 16%; P < .02), the SC group did not change (0.9%; P > 
      .05), and the SCO group tended to decline (-18%; P = .06). Both exercise 
      intervention groups significantly improved COT (Ex = 92%, ExO = 102%; P < .01) 
      and PWT (Ex = 54%, ExO = 103%; P < .001). There was no change (P > .05) in either 
      standard-of-care group. CONCLUSIONS: Individuals who are obese and nonobese with 
      PAD made similar improvements after a 6-month, center-based walking program. 
      However, patients who are obese with PAD and do not exercise may be susceptible 
      to greater declines in mobility. Exercise may be particularly important in 
      patients who are obese with PAD to avoid declines in mobility.
FAU - Addison, Odessa
AU  - Addison O
AD  - 1Department of Medicine, Division of Gerontology, University of Maryland, 
      Baltimore. 2Department of Veterans Affairs and Veterans Affairs Medical Center, 
      Geriatric Research, Education and Clinical Centers, Baltimore, Maryland. 
      3Department of Surgery, Division of Vascular Surgery, University of Maryland, 
      Baltimore. 4Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of 
      Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
FAU - Ryan, Alice S
AU  - Ryan AS
FAU - Prior, Steven J
AU  - Prior SJ
FAU - Katzel, Leslie I
AU  - Katzel LI
FAU - Kundi, Rishi
AU  - Kundi R
FAU - Lal, Brajesh K
AU  - Lal BK
FAU - Gardner, Andrew W
AU  - Gardner AW
LA  - eng
GR  - P30 AG028747/AG/NIA NIH HHS/United States
GR  - IK2 RX001788/RX/RRD VA/United States
GR  - R01 AG016685/AG/NIA NIH HHS/United States
GR  - K23 AG040775/AG/NIA NIH HHS/United States
GR  - T32 AG000219/AG/NIA NIH HHS/United States
GR  - P60 AG012583/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Geriatr Phys Ther
JT  - Journal of geriatric physical therapy (2001)
JID - 101142169
SB  - IM
MH  - Adult
MH  - Aged
MH  - Exercise Test
MH  - Exercise Therapy/*methods
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Intermittent Claudication/*epidemiology/*rehabilitation
MH  - Male
MH  - Middle Aged
MH  - Mobility Limitation
MH  - Obesity/*epidemiology/*rehabilitation
MH  - Treatment Outcome
MH  - Walking
PMC - PMC5182189
MID - NIHMS790171
EDAT- 2016/06/25 06:00
MHDA- 2018/07/17 06:00
PMCR- 2018/10/01
CRDT- 2016/06/25 06:00
PHST- 2016/06/25 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2016/06/25 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 10.1519/JPT.0000000000000096 [doi]
PST - ppublish
SO  - J Geriatr Phys Ther. 2017 Oct/Dec;40(4):190-196. doi: 
      10.1519/JPT.0000000000000096.