PMID- 27346433
OWN - NLM
STAT- MEDLINE
DCOM- 20180418
LR  - 20211204
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Jun 27
TI  - Kruppel-like Factor 4 modulates interleukin-6 release in human dendritic cells 
      after in vitro stimulation with Aspergillus fumigatus and Candida albicans.
PG  - 27990
LID - 10.1038/srep27990 [doi]
LID - 27990
AB  - Invasive fungal infections are associated with high mortality rates and are 
      mostly caused by the opportunistic fungi Aspergillus fumigatus and Candida 
      albicans. Immune responses against these fungi are still not fully understood. 
      Dendritic cells (DCs) are crucial players in initiating innate and adaptive 
      immune responses against fungal infections. The immunomodulatory effects of fungi 
      were compared to the bacterial stimulus LPS to determine key players in the 
      immune response to fungal infections. A genome wide study of the gene regulation 
      of human monocyte-derived dendritic cells (DCs) confronted with A. fumigatus, C. 
      albicans or LPS was performed and Kruppel-like factor 4 (KLF4) was identified as 
      the only transcription factor that was down-regulated in DCs by both fungi but 
      induced by stimulation with LPS. Downstream analysis demonstrated the influence 
      of KLF4 on the interleukine-6 expression in human DCs. Furthermore, KLF4 
      regulation was shown to be dependent on pattern recognition receptor ligation. 
      Therefore KLF4 was identified as a controlling element in the IL-6 immune 
      response with a unique expression pattern comparing fungal and LPS stimulation.
FAU - Czakai, Kristin
AU  - Czakai K
AD  - University Hospital of Wurzburg, Department of Internal Medicine II, WU4i, 
      Wurzburg, Germany.
FAU - Leonhardt, Ines
AU  - Leonhardt I
AD  - Septomics Research Centre, Friedrich Schiller University and Leibniz Institute 
      for Natural Product Research and Infection Biology-Hans-Knoll-Institute (HKI), 
      Jena, Germany.
FAU - Dix, Andreas
AU  - Dix A
AD  - Systems Biology/Bioinformatics, Leibniz Institute for Natural Product Research 
      and Infection Biology - Hans-Knoll-Institute, Jena, Germany.
FAU - Bonin, Michael
AU  - Bonin M
AD  - Institute of Medical Genetics and Applied Genomics, University of Tubingen, 
      Tubingen, Germany.
FAU - Linde, Joerg
AU  - Linde J
AD  - Systems Biology/Bioinformatics, Leibniz Institute for Natural Product Research 
      and Infection Biology - Hans-Knoll-Institute, Jena, Germany.
FAU - Einsele, Hermann
AU  - Einsele H
AD  - University Hospital of Wurzburg, Department of Internal Medicine II, WU4i, 
      Wurzburg, Germany.
FAU - Kurzai, Oliver
AU  - Kurzai O
AD  - Septomics Research Centre, Friedrich Schiller University and Leibniz Institute 
      for Natural Product Research and Infection Biology-Hans-Knoll-Institute (HKI), 
      Jena, Germany.
FAU - Loeffler, Jurgen
AU  - Loeffler J
AD  - University Hospital of Wurzburg, Department of Internal Medicine II, WU4i, 
      Wurzburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160627
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Aspergillosis/immunology/mortality/pathology
MH  - Aspergillus fumigatus/*immunology
MH  - Candida albicans/*immunology
MH  - Cell Line
MH  - Dendritic Cells/*immunology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Interleukin-6/*immunology/metabolism
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/*metabolism
MH  - Lipopolysaccharides/immunology
MH  - Pulmonary Aspergillosis/immunology/mortality/pathology
MH  - Receptors, Pattern Recognition/*metabolism
PMC - PMC4921831
EDAT- 2016/06/28 06:00
MHDA- 2018/04/19 06:00
PMCR- 2016/06/27
CRDT- 2016/06/28 06:00
PHST- 2016/03/24 00:00 [received]
PHST- 2016/05/26 00:00 [accepted]
PHST- 2016/06/28 06:00 [entrez]
PHST- 2016/06/28 06:00 [pubmed]
PHST- 2018/04/19 06:00 [medline]
PHST- 2016/06/27 00:00 [pmc-release]
AID - srep27990 [pii]
AID - 10.1038/srep27990 [doi]
PST - epublish
SO  - Sci Rep. 2016 Jun 27;6:27990. doi: 10.1038/srep27990.