PMID- 27346697
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20170827
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 77
IP  - 10
DP  - 2016 Oct
TI  - Association between KIR genotypes and HLA-B alleles on viral load in Southern 
      Brazilian individuals infected by HIV-1 subtypes B and C.
PG  - 854-860
LID - S0198-8859(16)30131-8 [pii]
LID - 10.1016/j.humimm.2016.06.013 [doi]
AB  - There is a great variety of HIV-1 subtypes circulating in Brazil, including 
      subtype C, whose prevalence is on the rise, particularly in the southern region. 
      Many host and viral genetic factors may be involved in this trend. We evaluated 
      the influence of human leukocyte antigen (HLA) class I alleles and killer-cell 
      immunoglobulin-like receptor (KIR) genotypes on viral set point and T-CD4(+) 
      parameters in 84 treatment-naive HIV-1-positive individuals. Frequency data in 
      the infected group were compared to data of 548 healthy control subjects. 
      Individuals with the KIR AA genotype had a higher viral load (VL) than 
      individuals with the KIR Bx genotype. The HIV-1 group was subdivided into three 
      subgroups according to HLA-B allele presence: those with protection to disease 
      alleles (HLA-B(+)), accelerated disease progression alleles (HLA-B(-)), or 
      neither (HLA-B(o)) were grouped. We observed a significant effect of the HLA-B 
      allele presence on VL. The HLA-B(+) group had significantly lower VL than the 
      HLA-B(-) group and trended toward a lower VL than the HLA-B(o) group. There were 
      significant differences between groups expressing extreme VL values: 
      KIR-AA+HLA-B(-) vs. KIR Bx+HLA-B(+) and KIR-AA+HLA-B(o)vs. KIR Bx+HLA-B(+). The 
      relationship of KIR/HLA host genetics with slow HIV disease progression in 
      southern Brazil may be useful for vaccine developers, epidemiologists, and 
      clinicians.
CI  - Copyright (c) 2016 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Fernandes-Cardoso, Juliana
AU  - Fernandes-Cardoso J
AD  - Laboratorio de Histocompatibilidade e Criopreservacao, Universidade do Estado do 
      Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Suffert, Theodoro Armando
AU  - Suffert TA
AD  - Servico de Assistencia Especializada em DST/AIDS, Prefeitura Municipal de Porto 
      Alegre, Porto Alegre, Brazil.
FAU - Correa, Maria da Gloria
AU  - Correa MDG
AD  - Servico de Assistencia Especializada em DST/AIDS, Prefeitura Municipal de Porto 
      Alegre, Porto Alegre, Brazil.
FAU - Jobim, Luiz Fernando Job
AU  - Jobim LFJ
AD  - Departamento de Imunologia, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      Brazil.
FAU - Jobim, Mariana
AU  - Jobim M
AD  - Departamento de Imunologia, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      Brazil.
FAU - Salim, Patricia Hartstein
AU  - Salim PH
AD  - Departamento de Imunologia, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      Brazil.
FAU - Arruda, Monica Barcelos
AU  - Arruda MB
AD  - Laboratorio de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio 
      de Janeiro, Brazil.
FAU - Boullosa, Lidia Theodoro
AU  - Boullosa LT
AD  - Laboratorio de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio 
      de Janeiro, Brazil.
FAU - Tanuri, Amilcar
AU  - Tanuri A
AD  - Laboratorio de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio 
      de Janeiro, Brazil.
FAU - Porto, Luis Cristovao
AU  - Porto LC
AD  - Laboratorio de Histocompatibilidade e Criopreservacao, Universidade do Estado do 
      Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Ferreira, Orlando C Jr
AU  - Ferreira OC Jr
AD  - Laboratorio de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio 
      de Janeiro, Brazil. Electronic address: jcardosobio@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160623
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B protein, human)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brazil
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HIV Infections/*genetics
MH  - HIV-1/*physiology
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptors, KIR/*genetics
MH  - *Viral Load
MH  - Young Adult
OTO - NOTNLM
OT  - Disease progression
OT  - HIV
OT  - HLA
OT  - KIR genotype
OT  - Viral load
EDAT- 2016/06/28 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/06/28 06:00
PHST- 2015/01/15 00:00 [received]
PHST- 2016/06/16 00:00 [revised]
PHST- 2016/06/20 00:00 [accepted]
PHST- 2016/06/28 06:00 [entrez]
PHST- 2016/06/28 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - S0198-8859(16)30131-8 [pii]
AID - 10.1016/j.humimm.2016.06.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2016 Oct;77(10):854-860. doi: 10.1016/j.humimm.2016.06.013. Epub 
      2016 Jun 23.