PMID- 27346740
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20190318
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 94
DP  - 2016 Sep
TI  - Respiratory medication sales and urban air pollution in Brussels (2005 to 2011).
PG  - 576-582
LID - S0160-4120(16)30237-9 [pii]
LID - 10.1016/j.envint.2016.06.019 [doi]
AB  - BACKGROUND: We investigated the associations between daily sales of respiratory 
      medication and air pollutants in the Brussels-Capital Region between 2005 and 
      2011. METHODS: We used over-dispersed Poisson Generalized Linear Models to 
      regress daily individual reimbursement data of prescribed asthma and COPD 
      medication from the social security database against each subject's residential 
      exposure to outdoor particulate matter (PM10) or NO2 estimated, by interpolation 
      from monitoring stations. We calculated cumulative risk ratios (RR) and their 95% 
      confidence intervals (CI) for interquartile ranges (IQR) of exposure for 
      different windows of past exposure for the entire population and for seven age 
      groups. RESULTS: Median daily concentrations of PM10 and NO2 were 25mug/m(3) 
      (IQR=17.1) and 38mug/m(3) (IQR=20.5), respectively. PM10 was associated with daily 
      medication sales among individuals aged 13 to 64y. For NO2, significant 
      associations were observed among all age groups except >84y. The highest RR were 
      observed for NO2, among adolescents, including three weeks lags (RR=1.187 95%CI: 
      1.097-1.285). CONCLUSION: The associations found between temporal changes in 
      exposure to air pollutants and daily sales of respiratory medication in Brussels 
      indicate that urban air pollution contributes to asthma and COPD morbidity in the 
      general population.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Casas, Lidia
AU  - Casas L
AD  - Centre for Environment and Health, Department of Public Health and Primary Care, 
      KU Leuven, Herestraat 49, 3000 Leuven, Belgium; ISGlobal, Centre for Research in 
      Environmental Epidemiology (CREAL), Dr Aiguader 88, 08003 Barcelona, Spain.
FAU - Simons, Koen
AU  - Simons K
AD  - Unit Health and Environment, Scientific Institute of Public Health, Juliette 
      Wytsmanstraat 14, 1050 Brussels, Belgium; Department of Biostatistics and Medical 
      Informatics, Public Health, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 
      Brussels, Belgium.
FAU - Nawrot, Tim S
AU  - Nawrot TS
AD  - Centre for Environment and Health, Department of Public Health and Primary Care, 
      KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Centre for Environmental 
      Sciences, Hasselt University, Hasselt, Belgium.
FAU - Brasseur, Olivier
AU  - Brasseur O
AD  - Department Laboratory and Air Quality, Brussels Environment, Gulledelle 100, 1200 
      Brussels, Belgium.
FAU - Declerck, Priscilla
AU  - Declerck P
AD  - Department Laboratory and Air Quality, Brussels Environment, Gulledelle 100, 1200 
      Brussels, Belgium.
FAU - Buyl, Ronald
AU  - Buyl R
AD  - Department of Biostatistics and Medical Informatics, Public Health, Vrije 
      Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
FAU - Coomans, Danny
AU  - Coomans D
AD  - Department of Biostatistics and Medical Informatics, Public Health, Vrije 
      Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
FAU - Nemery, Benoit
AU  - Nemery B
AD  - Centre for Environment and Health, Department of Public Health and Primary Care, 
      KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
FAU - Van Nieuwenhuyse, An
AU  - Van Nieuwenhuyse A
AD  - Unit Health and Environment, Scientific Institute of Public Health, Juliette 
      Wytsmanstraat 14, 1050 Brussels, Belgium. Electronic address: 
      An.VanNieuwenhuyse@wiv-isp.be.
LA  - eng
PT  - Journal Article
DEP - 20160623
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Air Pollutants)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Particulate Matter)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Air Pollutants/*analysis
MH  - Air Pollution/*analysis
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Belgium/epidemiology
MH  - Drug Prescriptions/*statistics & numerical data
MH  - Humans
MH  - Middle Aged
MH  - Nitrogen Dioxide/analysis
MH  - Particulate Matter/analysis
MH  - Young Adult
OTO - NOTNLM
OT  - *Asthma
OT  - *COPD
OT  - *air pollution
OT  - *medication sales
OT  - *time-series analyses
EDAT- 2016/06/28 06:00
MHDA- 2018/02/24 06:00
CRDT- 2016/06/28 06:00
PHST- 2016/02/23 00:00 [received]
PHST- 2016/05/26 00:00 [revised]
PHST- 2016/06/16 00:00 [accepted]
PHST- 2016/06/28 06:00 [entrez]
PHST- 2016/06/28 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
AID - S0160-4120(16)30237-9 [pii]
AID - 10.1016/j.envint.2016.06.019 [doi]
PST - ppublish
SO  - Environ Int. 2016 Sep;94:576-582. doi: 10.1016/j.envint.2016.06.019. Epub 2016 
      Jun 23.