PMID- 27348886
OWN - NLM
STAT- MEDLINE
DCOM- 20160802
LR  - 20160628
IS  - 0047-1917 (Print)
IS  - 0047-1917 (Linking)
VI  - 64
IP  - 1
DP  - 2016 Feb
TI  - Lambda cyhalothrin toxicity induces alterations in lipogenic genes and 
      inflammatory factors in rat liver.
PG  - 25-38
AB  - The present study aims to elucidate the molecular basis of lambda cyhalothrin 
      (LCT) toxicity. Thirty-two mature male albino rats were randomly classified into 
      four equal groups. The first group was orally administered normal saline, the 
      second group was orally administered dimethylsulfoxide (DMSO). The third group 
      was orally administered 1/100 LD50 (6.12 mg/kg b. wt) of a commercial formulation 
      containing 2.5% LCT (i.e., a net dose LCT corresponding to 0.15 mg/kg b. wt). The 
      fourth group was orally administered 1/100 LD50 (0.64 mg/kg b. wt) of a pure form 
      of LCT. The results indicated that exposure to LCT is capable of inducing an 
      up-regulation in the mRNA expression levels of peroxisome proliferative activated 
      receptor alpha and gamma (PPAR alpha and PPAR gamma), tumor necrosis factor (TNF-alpha), fatty acid 
      synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c). 
      Additionally, our study revealed a significant increase in serum levels of ALT, 
      AST, ALP, gammaGT as well as the inflammatory cytokines TNF-alpha and monocyte 
      chemoattractant protein-1 (MCP-1). A significant elevation in total lipids, total 
      cholesterol, triacylglycerol, LDL-c and leptin with a corresponding significant 
      decrease in HDL-c was also noted. Moreover, our results depicted that LCT 
      treatment exhibits a significant increase in hepatic MDA levels concurrent with a 
      significant decrease in GSH levels and the activities of CAT, SOD, and GPx. An 
      immunohistochemical investigation also revealed a strong up-regulation of hepatic 
      FAS in the LCT treated groups. The histopathological findings were marked by 
      evidence in support of periportal fatty changes and interstitial aggregation of 
      round cells.
FAU - Moustafa, Gihan G
AU  - Moustafa GG
FAU - Hussein, Mohamed M A
AU  - Hussein MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Vet Res
JT  - The Japanese journal of veterinary research
JID - 0376567
RN  - 0 (Antioxidants)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
RN  - V0V73PEB8M (cyhalothrin)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Fungicides, Industrial/toxicity
MH  - Gene Expression Regulation/drug effects
MH  - Inflammation/*metabolism
MH  - Lipogenesis/*drug effects
MH  - Liver/*drug effects/*metabolism/pathology
MH  - Male
MH  - Nitriles/*toxicity
MH  - Oxidation-Reduction
MH  - Pyrethrins/*toxicity
MH  - Rats
MH  - Rats, Wistar
EDAT- 2016/06/29 06:00
MHDA- 2016/08/03 06:00
CRDT- 2016/06/29 06:00
PHST- 2016/06/29 06:00 [entrez]
PHST- 2016/06/29 06:00 [pubmed]
PHST- 2016/08/03 06:00 [medline]
PST - ppublish
SO  - Jpn J Vet Res. 2016 Feb;64(1):25-38.