PMID- 27349335
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20181113
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 32
IP  - 10-11
DP  - 2016 Oct/Nov
TI  - Transmitted/Founder HIV-1 Subtype C Viruses Show Distinctive Signature Patterns 
      in Vif, Vpr, and Vpu That Are Under Subsequent Immune Pressure During Early 
      Infection.
PG  - 1031-1045
AB  - Viral variants that predominate during early infection may exhibit constrained 
      diversity compared with those found during chronic infection and could contain 
      amino acid signature patterns that may enhance transmission, establish productive 
      infection, and influence early events that modulate the infection course. We 
      compared amino acid distributions in 17 patients recently infected with HIV-1C 
      with patients with chronic infection. We found significantly lower entropy in 
      inferred transmitted/founder (t/f) compared with chronic viruses and identified 
      signature patterns in Vif and Vpr from inferred t/f viruses. We investigated 
      sequence evolution longitudinally up to 500 days postseroconversion and compared 
      the impact of selected substitutions on predicted human leukocyte antigen (HLA) 
      binding affinities of published and predicted cytotoxic T-lymphocyte epitopes. 
      Polymorphisms in Vif and Vpr during early infection occurred more frequently at 
      epitope-HLA anchor residues and significantly decreased predicted epitope-HLA 
      binding. Transmission-associated sequence signatures may have implications for 
      novel strategies to prevent HIV-1 transmission.
FAU - Rossenkhan, Raabya
AU  - Rossenkhan R
AD  - 1 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of 
      Public Health , Boston, Massachusetts.
AD  - 2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
AD  - 3 Department of Biological Sciences, University of Botswana , Gaborone, Botswana 
      .
AD  - 4 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research 
      Center , Seattle, Washington.
FAU - MacLeod, Iain J
AU  - MacLeod IJ
AD  - 1 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of 
      Public Health , Boston, Massachusetts.
AD  - 2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
FAU - Brumme, Zabrina L
AU  - Brumme ZL
AD  - 5 Faculty of Health Sciences, Simon Fraser University , Burnaby, Canada .
AD  - 6 British Columbia Centre for Excellence in HIV/AIDS , Vancouver, Canada .
FAU - Magaret, Craig A
AU  - Magaret CA
AD  - 4 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research 
      Center , Seattle, Washington.
FAU - Sebunya, Theresa K
AU  - Sebunya TK
AD  - 3 Department of Biological Sciences, University of Botswana , Gaborone, Botswana 
      .
FAU - Musonda, Rosemary
AU  - Musonda R
AD  - 1 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of 
      Public Health , Boston, Massachusetts.
AD  - 2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
FAU - Gashe, Berhanu A
AU  - Gashe BA
AD  - 3 Department of Biological Sciences, University of Botswana , Gaborone, Botswana 
      .
FAU - Edlefsen, Paul T
AU  - Edlefsen PT
AD  - 4 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research 
      Center , Seattle, Washington.
FAU - Novitsky, Vlad
AU  - Novitsky V
AD  - 1 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of 
      Public Health , Boston, Massachusetts.
AD  - 2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
FAU - Essex, M
AU  - Essex M
AD  - 1 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of 
      Public Health , Boston, Massachusetts.
AD  - 2 Botswana Harvard AIDS Institute , Gaborone, Botswana .
LA  - eng
GR  - D43 TW009610/TW/FIC NIH HHS/United States
GR  - UM1 AI068635/AI/NIAID NIH HHS/United States
GR  - R01 AI057027/AI/NIAID NIH HHS/United States
GR  - D43 TW000004/TW/FIC NIH HHS/United States
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160726
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Epitopes)
RN  - 0 (Human Immunodeficiency Virus Proteins)
RN  - 0 (Viral Regulatory and Accessory Proteins)
RN  - 0 (vif Gene Products, Human Immunodeficiency Virus)
RN  - 0 (vif protein, Human immunodeficiency virus 1)
RN  - 0 (vpr Gene Products, Human Immunodeficiency Virus)
RN  - 0 (vpr protein, Human immunodeficiency virus 1)
RN  - 0 (vpu protein, Human immunodeficiency virus 1)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Epitopes/genetics
MH  - Evolution, Molecular
MH  - Female
MH  - Genotype
MH  - HIV Infections/*transmission/*virology
MH  - HIV-1/*genetics/immunology/isolation & purification
MH  - Human Immunodeficiency Virus Proteins/*genetics
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Selection, Genetic
MH  - Viral Regulatory and Accessory Proteins/*genetics
MH  - vif Gene Products, Human Immunodeficiency Virus/*genetics
MH  - vpr Gene Products, Human Immunodeficiency Virus/*genetics
PMC - PMC5067802
OTO - NOTNLM
OT  - CTL epitope
OT  - HIV transmission
OT  - Vif
OT  - Vpr
OT  - Vpu
OT  - accessory genes
OT  - evolution
COIS- Author Disclosure Statement No competing financial interests exist.
EDAT- 2016/06/29 06:00
MHDA- 2017/12/19 06:00
PMCR- 2017/11/01
CRDT- 2016/06/29 06:00
PHST- 2016/06/29 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2016/06/29 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 10.1089/aid.2015.0330 [pii]
AID - 10.1089/AID.2015.0330 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2016 Oct/Nov;32(10-11):1031-1045. doi: 
      10.1089/AID.2015.0330. Epub 2016 Jul 26.