PMID- 27349571
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20171102
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 22
IP  - 10
DP  - 2016 Oct
TI  - Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict 
      Mortality in Chronic Heart Failure.
PG  - 823-8
LID - S1071-9164(16)30138-5 [pii]
LID - 10.1016/j.cardfail.2016.06.013 [doi]
AB  - BACKGROUND: Mitochondrial DNA (mtDNA) and possibly nuclear DNA (nDNA) are 
      released as danger-associated molecular patterns during cardiac stress, and may 
      activate several innate immune receptors. The purpose of this study was to 
      investigate the regulation of these danger-associated molecular patterns during 
      human heart failure (HF). METHODS AND RESULTS: Plasma levels of mtDNA and nDNA 
      from HF patients (n = 84) were analyzed by reverse transcriptase-polymerase chain 
      reaction and compared with controls (n = 72). Increased levels of mtDNA were 
      found in New York Heart Association (NYHA) I-II and NYHA III-IV. There was 
      evidence of increased nDNA in NYHA III-IV compared with controls and NYHA I-II. 
      Kaplan-Meier analysis revealed higher mortality in patients with high nDNA 
      levels, whereas high levels of mtDNA were associated with survival. CONCLUSIONS: 
      Plasma levels of mtDNA and nDNA are elevated in human HF associated with 
      increased and decreased mortality, respectively. This study may suggest a 
      rationale for exploring interventions within inflammatory signaling pathways 
      activated by nucleic acids as novel targets in treatment of HF.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Dhondup, Yangchen
AU  - Dhondup Y
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, 
      Oslo, Norway; Faculty of Medicine, University of Oslo, Norway. Electronic 
      address: yangched@gmail.com.
FAU - Ueland, Thor
AU  - Ueland T
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Norway.
FAU - Dahl, Christen Peder
AU  - Dahl CP
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway.
FAU - Askevold, Erik Tandberg
AU  - Askevold ET
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway.
FAU - Sandanger, Oystein
AU  - Sandanger O
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, 
      Oslo, Norway; Faculty of Medicine, University of Oslo, Norway.
FAU - Fiane, Arnt
AU  - Fiane A
AD  - Faculty of Medicine, University of Oslo, Norway; Department of Cardiothoracic 
      Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway.
FAU - Ohm, Ingrid Kristine
AU  - Ohm IK
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, 
      Oslo, Norway.
FAU - Sjaastad, Ivar
AU  - Sjaastad I
AD  - Center for Heart failure Research, University of Oslo, Oslo, Norway; Institute 
      for Experimental Research, Oslo University Hospital, Ulleval, Oslo, Norway.
FAU - Finsen, Alexandra Vanessa
AU  - Finsen AV
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, 
      Oslo, Norway.
FAU - Waehre, Anne
AU  - Waehre A
AD  - Center for Heart failure Research, University of Oslo, Oslo, Norway; Institute 
      for Experimental Research, Oslo University Hospital, Ulleval, Oslo, Norway.
FAU - Gullestad, Lars
AU  - Gullestad L
AD  - Center for Heart failure Research, University of Oslo, Oslo, Norway; Faculty of 
      Medicine, University of Oslo, Norway; Department of Cardiology, Oslo University 
      Hospital, Rikshospitalet, Oslo, Norway; K.G. Jebsen Cardiovascular Research 
      Center, University of Oslo, Oslo, Norway.
FAU - Aukrust, Pal
AU  - Aukrust P
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammation Research Center, 
      University of Oslo, Oslo, Norway; Faculty of Medicine, University of Oslo, 
      Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University 
      Hospital, Rikshospitalet, Oslo, Norway.
FAU - Yndestad, Arne
AU  - Yndestad A
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, 
      Oslo, Norway; Faculty of Medicine, University of Oslo, Norway.
FAU - Vinge, Leif Erik
AU  - Vinge LE
AD  - Research Institute of Internal Medicine, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of 
      Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital, 
      Rikshospitalet, Oslo, Norway; Department of Internal Medicine, Diakonhjemmet 
      Hospital, Oslo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20160624
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 0 (C1D protein, human)
RN  - 0 (Co-Repressor Proteins)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Co-Repressor Proteins/*metabolism
MH  - Female
MH  - Heart Failure/*blood/*mortality/physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mitochondria/*metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reference Values
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Survival Analysis
OTO - NOTNLM
OT  - DNA
OT  - innate immunity
OT  - mitochondria
OT  - toll-like receptor 9
EDAT- 2016/06/29 06:00
MHDA- 2017/11/03 06:00
CRDT- 2016/06/29 06:00
PHST- 2015/10/02 00:00 [received]
PHST- 2016/06/08 00:00 [revised]
PHST- 2016/06/23 00:00 [accepted]
PHST- 2016/06/29 06:00 [entrez]
PHST- 2016/06/29 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
AID - S1071-9164(16)30138-5 [pii]
AID - 10.1016/j.cardfail.2016.06.013 [doi]
PST - ppublish
SO  - J Card Fail. 2016 Oct;22(10):823-8. doi: 10.1016/j.cardfail.2016.06.013. Epub 
      2016 Jun 24.