PMID- 27350199
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20181202
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 68
IP  - 3
DP  - 2016 Jun 25
TI  - [Neuroprotective effects of a novel antidiabetic drug (D-Ser2)Oxm on amyloid beta 
      protein-induced cytotoxicity].
PG  - 265-75
AB  - The accumulation and neurotoxicity of amyloid beta protein (Abeta) in the brain is one 
      of major pathological hallmarks of Alzheimer's disease (AD). The effective drugs 
      against Abeta have been still deficient up to now. According to a most recent study, 
      (D-Ser2) Oxm, a new antidiabetic drug, not only improves the disorders in plasma 
      glucose and insulin in type 2 diabetes mellitus (T2DM) rats, but also exerts 
      positive effects on hippocampal neurogenesis and synaptogenesis. However, it is 
      still unclear whether (D-Ser2)Oxm can directly protect cultured neurons against 
      Abeta1-42-induced cytotoxicity. In the present study, we investigated the 
      neuroprotective effects of (D-Ser2)Oxm on the cultured primary hippocampal 
      neurons by testing the cell viability, neuronal apoptosis, mitochondrial membrane 
      potential and intracellular calcium concentration. The results showed that 
      treatment with (D-Ser2)Oxm effectively reversed Abeta1-42-induced decline in cell 
      viability (P < 0.001), and this protective effect could be inhibited by the 
      pretreatment with exendin(9-39), a GLP-1 receptor blocker. (D-Ser2)Oxm treatment 
      also decreased Abeta1-42-induced neuronal early apoptosis and down-regulated 
      apoptotic protein caspase3. Meantime, (D-Ser2)Oxm treatment inhibited 
      Abeta1-42-induced [Ca(2+)]i elevation, mitochondrial membrane potential 
      depolarization, and glycogen synthase kinase-3beta (GSK3beta) activation. These results 
      suggest that (D-Ser2)Oxm can protect hippocampal neurons against Abeta1-42-induced 
      cytotoxicity and this effect may be related to activation of GLP-1 receptors, 
      regulation of intracellular calcium homeostasis and stabilization of 
      mitochondrial membrane potential.
FAU - Han, Yu-Fei
AU  - Han YF
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Holscher, Christian
AU  - Holscher C
AD  - Division of Biomedical and Life Sciences, Faculty of Health and Medicine, 
      Lancaster University, Lancaster LA1 4YQ, UK.
FAU - Wang, Zhao-Jun
AU  - Wang ZJ
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Yuan, Li
AU  - Yuan L
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Tong, Jia-Qing
AU  - Tong JQ
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Wang, Dan-Dan
AU  - Wang DD
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Wu, Mei-Na
AU  - Wu MN
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China.
FAU - Qi, Jin-Shun
AU  - Qi JS
AD  - Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of 
      Education, Shanxi Medical University, Taiyuan 030001, China. 
      jinshunqi2009@163.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Neuroprotective Agents)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amyloid beta-Peptides
MH  - Animals
MH  - Calcium
MH  - Cell Survival
MH  - *Diabetes Mellitus, Type 2
MH  - Glucagon-Like Peptide-1 Receptor
MH  - Hippocampus
MH  - Hypoglycemic Agents
MH  - Insulin
MH  - Membrane Potential, Mitochondrial
MH  - Neurogenesis
MH  - Neurons
MH  - Neuroprotective Agents
MH  - Rats
EDAT- 2016/06/29 06:00
MHDA- 2017/05/02 06:00
CRDT- 2016/06/29 06:00
PHST- 2016/06/29 06:00 [entrez]
PHST- 2016/06/29 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
PST - ppublish
SO  - Sheng Li Xue Bao. 2016 Jun 25;68(3):265-75.