PMID- 27350825
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160628
LR  - 20200930
IS  - 1880-7046 (Print)
IS  - 1880-7062 (Electronic)
IS  - 1880-7046 (Linking)
VI  - 38
DP  - 2016
TI  - Mitochondrial complex I and V gene polymorphisms in type II diabetes mellitus 
      among high risk Mizo-Mongoloid population, Northeast India.
PG  - 5
LID - 10.1186/s41021-016-0034-z [doi]
LID - 5
AB  - INTRODUCTION: The study was carried out to identify the polymorphisms in 
      mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo 
      population and to correlate the involvement of demographic factors. FINDINGS: In 
      the present study, 58 patients and 50 healthy volunteers were considered. The 
      mutations observed were mostly base substitutions and were similar as reported 
      for other populations. Three mutations are unreported and were found to be novel 
      polymorphisms for diabetic disease. One heteroplasmic variation (MT3970 C > T) 
      was found in 36.36 % of samples. Subjects with excessive smoked meat consumption 
      and customary habit of smoking (ORs: 4.92; 95 % CI: 0.96-25.21) were found to be 
      more prone to T2DM. Mitochondrial genes sequence analysis revealed the genetic 
      variability between the healthy and diabetic samples. CONCLUSION: Mitochondrial 
      ATPase and ND1 gene polymorphisms may be involved in triggering the risk for 
      T2DM.
FAU - Lalrohlui, Freda
AU  - Lalrohlui F
AD  - Department of Biotechnology, Mizoram University, Aizawl, 796004 Mizoram India.
FAU - Thapa, Sunaina
AU  - Thapa S
AD  - Department of Biotechnology, Mizoram University, Aizawl, 796004 Mizoram India.
FAU - Ghatak, Souvik
AU  - Ghatak S
AD  - Department of Biotechnology, Mizoram University, Aizawl, 796004 Mizoram India.
FAU - Zohmingthanga, John
AU  - Zohmingthanga J
AD  - Department of Pathology, Civil Hospital, Aizawl, 796001 Mizoram India.
FAU - Senthil Kumar, Nachimuthu
AU  - Senthil Kumar N
AD  - Department of Biotechnology, Mizoram University, Aizawl, 796004 Mizoram India.
LA  - eng
PT  - Journal Article
DEP - 20160301
PL  - England
TA  - Genes Environ
JT  - Genes and environment : the official journal of the Japanese Environmental 
      Mutagen Society
JID - 101285347
PMC - PMC4917945
OTO - NOTNLM
OT  - Demography
OT  - Genetic variability
OT  - Mitochondrial genes
OT  - Polymorphism
OT  - Type 2 diabetes mellitus
EDAT- 2016/06/29 06:00
MHDA- 2016/06/29 06:01
PMCR- 2016/03/01
CRDT- 2016/06/29 06:00
PHST- 2015/11/12 00:00 [received]
PHST- 2016/02/03 00:00 [accepted]
PHST- 2016/06/29 06:00 [entrez]
PHST- 2016/06/29 06:00 [pubmed]
PHST- 2016/06/29 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 34 [pii]
AID - 10.1186/s41021-016-0034-z [doi]
PST - epublish
SO  - Genes Environ. 2016 Mar 1;38:5. doi: 10.1186/s41021-016-0034-z. eCollection 2016.