PMID- 27351563
OWN - NLM
STAT- MEDLINE
DCOM- 20171215
LR  - 20181113
IS  - 1867-0687 (Electronic)
VI  - 12
IP  - 3
DP  - 2016 Aug
TI  - Allergen specific sublingual immunotherapy in children with asthma and allergic 
      rhinitis.
PG  - 283-290
LID - 10.1007/s12519-016-0022-1 [doi]
AB  - BACKGROUND: The incidence of asthma and allergic rhinitis (AR) is significantly 
      increased, especially in younger children. Current treatment for children with 
      asthma and allergic rhinitis include allergen avoidance, standard 
      pharmacotherapy, and immunotherapy. Since standard pharmacotherapy is prescribed 
      for symptoms, immunotherapy at present plays an important role in the treatment 
      of allergic diseases. This article presents insights into the up-to-date 
      understanding of immunotherapy in the treatment of children with allergic 
      rhinitis and asthma. DATA SOURCES: PubMed articles published from 1990 to 2014 
      were reviewed using the MeSH terms "asthma", "allergic rhinitis", "children", and 
      "immune therapy". Additional articles were identified by hand searching of the 
      references in the initial search. RESULTS: Numerous studies have shown that 
      sublingual application of allergen specific immunotherapy (SLIT) is an adequate, 
      safe and efficient substitution to subcutaneous route of allergens administration 
      (SCIT) in the treatment of IgE-mediated respiratory tract allergies in children. 
      According to the literature, better clinical efficacy is connected with the 
      duration of treatment and mono sensitized patients. CONCLUSIONS: At least 3 years 
      of treatment and stable asthma before the immunotherapy are positive predictors 
      of good clinical efficacy and tolerability of SLIT. SLIT reduces the symptoms of 
      allergic diseases and the use of medicaments, and improves the quality of life of 
      children with the diseases.
FAU - Duric-Filipovic, Ivana
AU  - Duric-Filipovic I
AD  - Faculty of Medical Science Kragujevac, Department of Immunology, Svetozara 
      Markovica 69, Kragujevac, 34000, Serbia. drivanica@yahoo.com.
FAU - Caminati, Marco
AU  - Caminati M
AD  - Unita di Allergologia Centro Regionale di riferimento per la prevenzione, la 
      diagnosi e la terapia delle malattie allergiche Ospedale Universitario Borgo 
      Trento, Piazzale Stefani 1, Verona, Italy.
FAU - Kostic, Gordana
AU  - Kostic G
AD  - Children's Hospital, Clinical Centre Kragujevac, Zmaj Jovina 30, 34000, 
      Kragujevac, Serbia.
FAU - Filipovic, Dorde
AU  - Filipovic D
AD  - Institution for Emergency Medical Care, Bulevar Fransa Depera 5, 11000, Belgrade, 
      Serbia.
FAU - Zivkovic, Zorica
AU  - Zivkovic Z
AD  - Children's Hospital for Lung Diseases and Tuberculosis, Medical Center "Dr 
      Dragisa Misovic", Heroja Mihajla Tepica 1, 11000, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160629
PL  - Switzerland
TA  - World J Pediatr
JT  - World journal of pediatrics : WJP
JID - 101278599
RN  - 0 (Allergens)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Asthma/*immunology/psychology/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Desensitization, Immunologic/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - *Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Rhinitis, Allergic/diagnosis/psychology/*therapy
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sublingual Immunotherapy/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - allergic asthma
OT  - allergic rhinitis
OT  - allergic sensitization
OT  - immunotherapy
EDAT- 2016/06/29 06:00
MHDA- 2017/12/16 06:00
CRDT- 2016/06/29 06:00
PHST- 2014/03/26 00:00 [received]
PHST- 2015/01/02 00:00 [accepted]
PHST- 2016/06/29 06:00 [entrez]
PHST- 2016/06/29 06:00 [pubmed]
PHST- 2017/12/16 06:00 [medline]
AID - 10.1007/s12519-016-0022-1 [pii]
AID - 10.1007/s12519-016-0022-1 [doi]
PST - ppublish
SO  - World J Pediatr. 2016 Aug;12(3):283-290. doi: 10.1007/s12519-016-0022-1. Epub 
      2016 Jun 29.