PMID- 27352803
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20220408
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Print)
IS  - 1368-5031 (Linking)
VI  - 70
IP  - 7
DP  - 2016 Jul
TI  - IgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship 
      with inflammatory phenotypes and disease severity.
PG  - 596-605
LID - 10.1111/ijcp.12837 [doi]
AB  - BACKGROUND: Atopy is known to play an important role in the asthmatic disease. 
      The main objective of this study was to evaluate the frequency of sensitisation 
      to common aeroallergens in a cohort of asthmatics with different inflammatory 
      phenotypes and disease severity. METHODS: We have conducted a retrospective 
      cross-sectional study including 772 asthmatics recruited between 2003 and 2014 in 
      our Asthma Clinic. The patients were defined as asthmatics on the basis of 
      respiratory symptoms together with a positive methacholine test (PC20M) < 16 
      mg/ml and/or a reversibility to short-acting beta2-agonists (salbutamol) >/= 12% and 
      200 ml. Sensitisation to house dust mites, grass and birch pollens, cats, dogs 
      and moulds was assessed by RAST and a specific immunoglobulin E (IgE) > 0.35 kU/l 
      was considered as significant. Inflammatory phenotypes were subdivided between 
      pauci-granulocytic (n = 309) (40%), eosinophilic (n = 311) (40%), neutrophilic (N 
      = 134) (17%) and mixed-granulocytic (N = 18) (3%) asthmatics. Severe asthmatics 
      (n = 118) were defined according to the American Thoracic Society (ATS 2000) 
      criteria and compared with mild-to-moderate asthmatics (N = 654). RESULTS: The 
      eosinophilic phenotype was associated with higher levels of total serum IgE 
      compared with neutrophilic and pauci-granulocytic asthma (p < 0.001 for both). 
      Sensitisation rate to dogs and cats was higher in eosinophilic asthmatics (31% 
      and 37%, respectively, p < 0.01 both) compared with neutrophilic (18% and 23% 
      respectively) and pauci-granulocytic asthmatics (20% and 24%, respectively), 
      while sensitisation rate to house dust mites and moulds were rather similar 
      between the groups (ranging from 33% to 40% and from 10% to 16%, respectively). 
      Severe asthmatics had slightly increased total serum IgE compared with 
      mild-to-moderate asthmatics (p < 0.05) without any difference in the 
      sensitisation rate to common aeroallergens. CONCLUSION: Eosinophilic asthma 
      exhibits higher total serum IgE and sensitisation rate towards animal dander 
      while clinical severity, though also associated with higher total IgE, did not 
      preferentially relate to any type of common aeroallergens.
CI  - (c) 2016 The Authors. International Journal of Clinical Practice Published by John 
      Wiley & Sons Ltd.
FAU - Manise, M
AU  - Manise M
AD  - Department of Respiratory Medicine, CHU Sart-Tilman, Liege, Belgium.
AD  - GIGA Research Group i3, Liege, Belgium.
FAU - Bakayoko, B
AU  - Bakayoko B
AD  - Department of Respiratory Medicine, CHU Sart-Tilman, Liege, Belgium.
AD  - GIGA Research Group i3, Liege, Belgium.
FAU - Schleich, F
AU  - Schleich F
AD  - Department of Respiratory Medicine, CHU Sart-Tilman, Liege, Belgium.
AD  - GIGA Research Group i3, Liege, Belgium.
FAU - Corhay, J-L
AU  - Corhay JL
AD  - Department of Respiratory Medicine, CHU Sart-Tilman, Liege, Belgium.
AD  - GIGA Research Group i3, Liege, Belgium.
FAU - Louis, R
AU  - Louis R
AD  - Department of Respiratory Medicine, CHU Sart-Tilman, Liege, Belgium.
AD  - GIGA Research Group i3, Liege, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20160628
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Asthma/blood/*immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/blood/*immunology
MH  - Inflammation/immunology
MH  - Male
MH  - Middle Aged
MH  - Radioallergosorbent Test
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC5094514
EDAT- 2016/06/30 06:00
MHDA- 2017/09/02 06:00
PMCR- 2016/11/03
CRDT- 2016/06/30 06:00
PHST- 2016/06/30 06:00 [entrez]
PHST- 2016/06/30 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
PHST- 2016/11/03 00:00 [pmc-release]
AID - IJCP12837 [pii]
AID - 10.1111/ijcp.12837 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2016 Jul;70(7):596-605. doi: 10.1111/ijcp.12837. Epub 2016 Jun 
      28.