PMID- 27352886
OWN - NLM
STAT- MEDLINE
DCOM- 20170519
LR  - 20180106
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 65
IP  - 10
DP  - 2016 Oct
TI  - Cardiac Autonomic Function Is Associated With the Coronary Microcirculatory 
      Function in Patients With Type 2 Diabetes.
PG  - 3129-38
LID - 10.2337/db16-0437 [doi]
AB  - Cardiac autonomic dysfunction and cardiac microvascular dysfunction are diabetic 
      complications associated with increased mortality, but the association between 
      these has been difficult to assess. We applied new and sensitive methods to 
      assess this in patients with type 2 diabetes mellitus (T2DM). In a 
      cross-sectional design, coronary flow reserve (CFR) assessed by cardiac 
      (82)Rb-positron emission tomography/computed tomography, cardiac autonomic reflex 
      tests, and heart rate variability indices were performed in 55 patients with 
      T2DM, without cardiovascular disease, and in 28 control subjects. Cardiac 
      (123)I-metaiodobenzylguanidine scintigraphy was conducted in a subgroup of 29 
      patients and 14 control subjects and evaluated as the late heart-to-mediastinum 
      ratio and washout rate. Impaired function of all the cardiac autonomic measures 
      (except the washout rate) was associated with reduced CFR. A heart rate 
      variability index, reflecting sympathetic and parasympathetic function 
      (low-frequency power), and the late heart-to-mediastinum ratio, reflecting the 
      function of adrenergic receptors and sympathetic activity, were positively 
      correlated with CFR after adjustment for age and heart rate. The late heart-to- 
      mediastinum ratio remained correlated with CFR after further adjustment. In 
      patients with T2DM without cardiovascular disease, we demonstrate an independent 
      association between cardiac autonomic function and CFR. We suggest that a reduced 
      cardiac autonomic function and damage to the adrenergic receptors may contribute 
      to the development of cardiac microvascular dysfunction.
CI  - (c) 2016 by the American Diabetes Association.
FAU - von Scholten, Bernt Johan
AU  - von Scholten BJ
AD  - Steno Diabetes Center, Gentofte, Denmark bjos@steno.dk.
FAU - Hansen, Christian Stevns
AU  - Hansen CS
AD  - Steno Diabetes Center, Gentofte, Denmark.
FAU - Hasbak, Philip
AU  - Hasbak P
AD  - Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for 
      Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Kjaer, Andreas
AU  - Kjaer A
AD  - Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for 
      Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Rossing, Peter
AU  - Rossing P
AD  - Steno Diabetes Center, Gentofte, Denmark University of Copenhagen, Copenhagen, 
      Denmark Aarhus University, Aarhus, Denmark.
FAU - Hansen, Tine Willum
AU  - Hansen TW
AD  - Steno Diabetes Center, Gentofte, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160628
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/metabolism/physiopathology
MH  - Autonomic Nervous System/metabolism/*physiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology
MH  - Female
MH  - Heart/physiology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Microcirculation/*physiology
MH  - Middle Aged
EDAT- 2016/06/30 06:00
MHDA- 2017/05/20 06:00
CRDT- 2016/06/30 06:00
PHST- 2016/04/04 00:00 [received]
PHST- 2016/06/22 00:00 [accepted]
PHST- 2016/06/30 06:00 [entrez]
PHST- 2016/06/30 06:00 [pubmed]
PHST- 2017/05/20 06:00 [medline]
AID - db16-0437 [pii]
AID - 10.2337/db16-0437 [doi]
PST - ppublish
SO  - Diabetes. 2016 Oct;65(10):3129-38. doi: 10.2337/db16-0437. Epub 2016 Jun 28.