PMID- 27353857
OWN - NLM
STAT- MEDLINE
DCOM- 20171213
LR  - 20180104
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 312
DP  - 2016 Oct 1
TI  - Involvement of glutamatergic N-methyl-d-aspartate receptors in the expression of 
      increased head-dipping behaviors in the hole-board tests of olfactory 
      bulbectomized mice.
PG  - 313-20
LID - S0166-4328(16)30410-7 [pii]
LID - 10.1016/j.bbr.2016.06.045 [doi]
AB  - Olfactory bulbectomized (OB) mice produce agitated anxiety-like behaviors in the 
      hole-board test, which was expressed by an increase in head-dipping counts and a 
      decrease in head-dipping latencies. However, the associated mechanisms remain 
      unclear. In the present study, MK-801 (10, 100mug/kg), a selective 
      N-methyl-d-aspartate (NMDA) receptor antagonist, significantly and 
      dose-dependently suppressed the increased head-dipping behaviors in OB mice, 
      without affecting sham mice. Similar results were obtained with another selective 
      NMDA receptor antagonist D-AP5 treatment in OB mice. On the other hand, muscimol, 
      a selective aminobutyric acid type A (GABAA) receptor agonist produced no effects 
      on these hyperemotional behaviors in OB mice at a dose (100mug/kg) that produced 
      anxiolytic-like effects in sham mice. Interestingly, glutamine contents and 
      glutamine/glutamate ratios were significantly increased in the amygdala and 
      frontal cortex of OB mice compared to sham mice. Based on these results, we 
      concluded that the glutamatergic NMDA receptors are involved in the expression of 
      increased head-dipping behaviors in the hole-board tests of OB mice. Accordingly, 
      the changes in glutamatergic transmission in frontal cortex and amygdala may play 
      important roles in the expression of these abnormal behaviors in OB mice.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Hirose, Noritaka
AU  - Hirose N
AD  - Department of Pathophysiology and Therapeutics, Hoshi University School of 
      Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, 
      Japan.
FAU - Saitoh, Akiyoshi
AU  - Saitoh A
AD  - Department of Pathophysiology and Therapeutics, Hoshi University School of 
      Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, 
      Japan. Electronic address: asaitoh@ncnp.go.jp.
FAU - Kamei, Junzo
AU  - Kamei J
AD  - Department of Pathophysiology and Therapeutics, Hoshi University School of 
      Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20160625
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA-A Receptor Agonists)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0RH81L854J (Glutamine)
RN  - 2763-96-4 (Muscimol)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Amygdala/metabolism
MH  - Animals
MH  - Anti-Anxiety Agents/administration & dosage
MH  - Anxiety/*physiopathology
MH  - Disease Models, Animal
MH  - Dizocilpine Maleate/administration & dosage
MH  - Excitatory Amino Acid Antagonists/administration & dosage
MH  - Exploratory Behavior/drug effects/*physiology
MH  - Frontal Lobe/metabolism
MH  - GABA-A Receptor Agonists/administration & dosage
MH  - Glutamic Acid/metabolism
MH  - Glutamine/metabolism
MH  - Head Movements/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Motor Activity/drug effects
MH  - Muscimol/administration & dosage
MH  - Olfactory Bulb/*surgery
MH  - Receptors, GABA-A/physiology
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*physiology
MH  - gamma-Aminobutyric Acid/metabolism
OTO - NOTNLM
OT  - Amygdala
OT  - Animal model
OT  - Anxiety
OT  - Frontal cortex
OT  - Glutamate
OT  - Olfactory bulbectomy
EDAT- 2016/06/30 06:00
MHDA- 2017/12/14 06:00
CRDT- 2016/06/30 06:00
PHST- 2016/04/21 00:00 [received]
PHST- 2016/06/21 00:00 [revised]
PHST- 2016/06/24 00:00 [accepted]
PHST- 2016/06/30 06:00 [entrez]
PHST- 2016/06/30 06:00 [pubmed]
PHST- 2017/12/14 06:00 [medline]
AID - S0166-4328(16)30410-7 [pii]
AID - 10.1016/j.bbr.2016.06.045 [doi]
PST - ppublish
SO  - Behav Brain Res. 2016 Oct 1;312:313-20. doi: 10.1016/j.bbr.2016.06.045. Epub 2016 
      Jun 25.