PMID- 27354131
OWN - NLM
STAT- MEDLINE
DCOM- 20170621
LR  - 20220317
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 95
IP  - 4
DP  - 2016 Jul 15
TI  - Role of Adjuvant Radiation Therapy After Surgery for Abdominal Desmoplastic Small 
      Round Cell Tumors.
PG  - 1244-53
LID - S0360-3016(16)00179-6 [pii]
LID - 10.1016/j.ijrobp.2016.02.046 [doi]
AB  - PURPOSE: To identify the prognostic role of adjuvant abdominal radiation therapy 
      (RT) on oncologic outcomes as a part of multimodal treatment in the management of 
      desmoplastic small round cell tumor (DSRCT) and to determine its impact according 
      to the quality of surgical resection. METHODS AND MATERIALS: All patients treated 
      for primary abdominal DSRCT in 8 French centers from 1991 to 2014 were included. 
      Patients were retrospectively staged into 3 groups: group A treated with adjuvant 
      RT after cytoreductive surgery, group B without RT after cytoreductive surgery, 
      and group C by exclusive chemotherapy. Peritoneal progression-free survival 
      (PPFS), progression-free survival (PFS), and overall survival (OS) were 
      evaluated. We also performed a direct comparison between groups A and B to 
      evaluate RT after cytoreductive surgery. Radiation therapy was also evaluated 
      according to completeness of surgery: complete cytoreductive surgery (CCS) or 
      incomplete cytoreductive surgery (ICS). RESULTS: Thirty-seven (35.9%), thirty-six 
      (34.9%), and thirty (28.0%) patients were included in groups A, B, and C, 
      respectively. Three-year OS was 61.2% (range, 41.0%-76.0%), 37.6% (22.0%-53.1%), 
      and 17.3% (6.3%-32.8%) for groups A, B, and C, respectively. Overall survival, 
      PPFS, and PFS differed significantly among the 3 groups (P<.001, P<.001, and 
      P<.001, respectively). Overall survival and PPFS were higher in group A (RT 
      group) compared with group B (no RT group) (P=.045 and P=.006, respectively). 
      Three-year PPFS was 23.8% (10.3%-40.4%) for group A and 12.51% (4.0%-26.2%) for 
      group B. After CCS, RT improved PPFS (P=.024), but differences in OS and PFS were 
      not significant (P=.40 and P=.30, respectively). After ICS, RT improved OS 
      (P=.044). A trend of PPFS and PFS increase was observed, but the difference was 
      not statistically significant (P=.073 and P=.076). CONCLUSIONS: Adjuvant RT as 
      part of multimodal treatment seems to confer oncologic benefits for patients 
      treated for abdominal DSRCT after cytoreductive surgery and perioperative 
      chemotherapy.
CI  - Copyright (c) 2016. Published by Elsevier Inc.
FAU - Atallah, Vincent
AU  - Atallah V
AD  - Department of Radiation Oncology, Bergonie Institute, Bordeaux, France.
FAU - Honore, Charles
AU  - Honore C
AD  - Department of Digestive Surgery, Gustave-Roussy Institute, Paris, France.
FAU - Orbach, Daniel
AU  - Orbach D
AD  - Department of Pediatric Oncology, Curie Institute, Paris, France.
FAU - Helfre, Sylvie
AU  - Helfre S
AD  - Department of Pediatric Oncology, Curie Institute, Paris, France.
FAU - Ducassou, Anne
AU  - Ducassou A
AD  - Department of Radiation Oncology, Universitary Cancer Institute, Toulouse, 
      France.
FAU - Thomas, Laurence
AU  - Thomas L
AD  - Department of Radiation Oncology, Bergonie Institute, Bordeaux, France.
FAU - Levitchi, Mihai-Barbu
AU  - Levitchi MB
AD  - Department of Radiation Oncology, Alexis-Vautrin Center, Nancy, France.
FAU - Mervoyer, Augustin
AU  - Mervoyer A
AD  - Department of Radiation Oncology, Cancerologie de l'ouest Institute, Nantes, 
      France.
FAU - Naji, Salem
AU  - Naji S
AD  - Department of Radiation Oncology, Paoli-Calmette Institute, Marseille, France.
FAU - Dupin, Charles
AU  - Dupin C
AD  - Department of Radiation Oncology, Universitary Hospital, Bordeaux, France.
FAU - Bosco-Levy, Pauline J
AU  - Bosco-Levy PJ
AD  - Department of Radiation Oncology, Bergonie Institute, Bordeaux, France.
FAU - Philippe-Chomette, Pascale
AU  - Philippe-Chomette P
AD  - Department of Pediatric Surgery, University Paris 7 Denis Diderot, Hopital Robert 
      Debre, Assistance Publique-Hopitaux de Paris, Paris, France.
FAU - Kantor, Guy
AU  - Kantor G
AD  - Department of Radiation Oncology, Bergonie Institute, Bordeaux, France.
FAU - Henriques de Figueiredo, Benedicte
AU  - Henriques de Figueiredo B
AD  - Department of Radiation Oncology, Bergonie Institute, Bordeaux, France.
FAU - Sunyach, Marie-Pierre
AU  - Sunyach MP
AD  - Department of Radiation Oncology, Leon-Berard Center, Lyon, France.
FAU - Sargos, Paul
AU  - Sargos P
AD  - Department of Radiation Oncology, Bergonie Institute, Bordeaux, France. 
      Electronic address: p.sargos@bordeaux.unicancer.fr.
LA  - eng
PT  - Journal Article
DEP - 20160219
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Abdominal Neoplasms/mortality/*radiotherapy/surgery
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Desmoplastic Small Round Cell Tumor/mortality/*radiotherapy/surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiotherapy, Adjuvant
MH  - Retrospective Studies
EDAT- 2016/06/30 06:00
MHDA- 2017/06/22 06:00
CRDT- 2016/06/30 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2016/02/08 00:00 [revised]
PHST- 2016/02/15 00:00 [accepted]
PHST- 2016/06/30 06:00 [entrez]
PHST- 2016/06/30 06:00 [pubmed]
PHST- 2017/06/22 06:00 [medline]
AID - S0360-3016(16)00179-6 [pii]
AID - 10.1016/j.ijrobp.2016.02.046 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1244-53. doi: 
      10.1016/j.ijrobp.2016.02.046. Epub 2016 Feb 19.