PMID- 27355242
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20171116
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 48
IP  - 9
DP  - 2016 Sep
TI  - Insulin-Like Peptide 5 Interacts with Sex Hormones and Metabolic Parameters in a 
      Gender and Adiposity Dependent Manner in Humans.
PG  - 589-94
LID - 10.1055/s-0042-109869 [doi]
AB  - Insulin-like peptide 5 (INSL5) is a gut hormone produced by L-cells in the 
      colorectal epithelium and may play a role in the regulation of metabolic 
      processes. The biological role of INSL5 is poorly investigated and nothing is 
      known about the role of this hormone in obese and lean humans. Two cohorts were 
      analyzed in the study. In the first cohort (n=76) the relationship between serum 
      levels of INSL5 and different metabolic and hormonal parameters in obese and lean 
      men and women were investigated. In the second cohort 14 male subjects underwent 
      bariatric surgery. Circulating levels of INSL5 were then measured before and 
      after interventions.We report for the first time that circulating INSL5 interacts 
      with multiple metabolic and hormonal variables in lean and obese men and women 
      and is affected by bariatric surgery. Serum levels of INSL5 negatively correlated 
      with testosterone and blood lipids but positively with cortisol in obese men. In 
      contrast to males, obese women had a strong negative correlation of plasma levels 
      of INSL5 with C-reactive protein (CRP). We observed that adipose tissue loss 
      after bariatric surgery significantly reduced serum levels of INSL5 in obese men 
      with and without Type 2 Diabetes Mellitus (T2DM) that was associated with the 
      restoration of circulating levels of testosterone. All together, our data 
      demonstrated that INSL5 may interact with some metabolic parameters in obese 
      humans and this process is dependent of gender and obesity state.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Wagner, I V
AU  - Wagner IV
AD  - Department of Women and Child Health, Pediatric Endocrinology Unit, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Flehmig, G
AU  - Flehmig G
AD  - Division of Endocrinology, Department of Medicine, University of Leipzig, 
      Leipzig, Germany.
FAU - Scheuermann, K
AU  - Scheuermann K
AD  - Center for Pediatric Research Leipzig, Department of Women's and Child Health, 
      University Hospital for Children & Adolescents, University of Leipzig, Leipzig, 
      Germany.
FAU - Loffler, D
AU  - Loffler D
AD  - Center for Pediatric Research Leipzig, Department of Women's and Child Health, 
      University Hospital for Children & Adolescents, University of Leipzig, Leipzig, 
      Germany.
FAU - Korner, A
AU  - Korner A
AD  - Center for Pediatric Research Leipzig, Department of Women's and Child Health, 
      University Hospital for Children & Adolescents, University of Leipzig, Leipzig, 
      Germany.
FAU - Kiess, W
AU  - Kiess W
AD  - Center for Pediatric Research Leipzig, Department of Women's and Child Health, 
      University Hospital for Children & Adolescents, University of Leipzig, Leipzig, 
      Germany.
FAU - Stumvoll, M
AU  - Stumvoll M
AD  - Integrated Research and Treatment Center (IFB Adiposity Diseases), University of 
      Leipzig, Leipzig, Germany.
FAU - Dietrich, A
AU  - Dietrich A
AD  - Integrated Research and Treatment Center (IFB Adiposity Diseases), University of 
      Leipzig, Leipzig, Germany.
FAU - Bluher, M
AU  - Bluher M
AD  - Integrated Research and Treatment Center (IFB Adiposity Diseases), University of 
      Leipzig, Leipzig, Germany.
FAU - Kloting, N
AU  - Kloting N
AD  - Integrated Research and Treatment Center (IFB Adiposity Diseases), University of 
      Leipzig, Leipzig, Germany.
FAU - Soder, O
AU  - Soder O
AD  - Department of Women and Child Health, Pediatric Endocrinology Unit, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Svechnikov, K
AU  - Svechnikov K
AD  - Department of Women and Child Health, Pediatric Endocrinology Unit, Karolinska 
      Institutet, Stockholm, Sweden.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160629
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Biomarkers)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Insulin)
RN  - 0 (Leydig insulin-like protein)
RN  - 0 (Proteins)
SB  - IM
MH  - *Adiposity
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*metabolism
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Gonadal Steroid Hormones/*metabolism
MH  - Humans
MH  - Insulin/*metabolism
MH  - Male
MH  - Metabolic Syndrome/etiology/*metabolism/pathology
MH  - Middle Aged
MH  - Obesity/*complications/physiopathology
MH  - Prognosis
MH  - Proteins/*metabolism
MH  - Thinness/*complications/physiopathology
MH  - Young Adult
EDAT- 2016/06/30 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/06/30 06:00
PHST- 2016/06/30 06:00 [entrez]
PHST- 2016/06/30 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
AID - 10.1055/s-0042-109869 [doi]
PST - ppublish
SO  - Horm Metab Res. 2016 Sep;48(9):589-94. doi: 10.1055/s-0042-109869. Epub 2016 Jun 
      29.