PMID- 27356420
OWN - NLM
STAT- MEDLINE
DCOM- 20160802
LR  - 20160630
IS  - 1005-6661 (Print)
IS  - 1005-6661 (Linking)
VI  - 28
IP  - 1
DP  - 2016 Feb
TI  - [Advances in researches on beta-carbonic anhydrases as anti-parasitic drug targets].
PG  - 99-102
AB  - beta-carbonic anhydrases (beta-CAs) are ubiquitous metalloenzymes which active site 
      contains a zinc ion (Zn(2)(+)), and they could catalyze the hydration of carbon 
      dioxide to bicarbonate and protons efficiently and are involved in many 
      biological processes, such as respiration, pH and CO(2) homeostasis, biosynthetic 
      reactions, virulence regulation and so on, and may play a critical role in the 
      life activity of many organisms which contain these enzymes. beta-CAs are widely 
      distributed in fungi, bacteria, algae, plants and a small number of protozoan and 
      metazoan except vertebrates. Therefore, as potential drug targets for designing 
      and developing antibacterial and anti-parasitic drugs, beta-CAs promise a broad 
      application prospect. This paper focuses on the distribution, physiological 
      function and the progress of researches on beta-CAs in parasites and their vectors.
FAU - Zhang, Cong-hui
AU  - Zhang CH
FAU - Zhu, Huai-min
AU  - Zhu HM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
JT  - Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis 
      control
JID - 101144973
RN  - 0 (Antiparasitic Agents)
RN  - 0 (Carbonic Anhydrase Inhibitors)
RN  - EC 4.2.1.1 (Carbonic Anhydrases)
SB  - IM
MH  - Animals
MH  - Antiparasitic Agents/*pharmacology
MH  - Carbonic Anhydrase Inhibitors/*pharmacology
MH  - Carbonic Anhydrases/*physiology
MH  - Drug Design
MH  - Humans
EDAT- 2016/07/01 06:00
MHDA- 2016/08/03 06:00
CRDT- 2016/07/01 06:00
PHST- 2016/07/01 06:00 [entrez]
PHST- 2016/07/01 06:00 [pubmed]
PHST- 2016/08/03 06:00 [medline]
PST - ppublish
SO  - Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2016 Feb;28(1):99-102.