PMID- 27356468
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20170908
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 239
IP  - 3
DP  - 2016 Jul
TI  - Donor-Derived Regulatory T Cells Attenuate the Severity of Acute 
      Graft-Versus-Host Disease after Cord Blood Transplantation.
PG  - 193-202
LID - 10.1620/tjem.239.193 [doi]
AB  - Allogeneic peripheral blood stem cell transplantation (allo-PBSCT) is a curative 
      therapy for some types of hematological disorders. However, allo-PBSCT is 
      commonly complicated with acute graft-versus-host disease (aGVHD), characterized 
      by host tissues being attacked by the grafted donor lymphocytes due to 
      disparities of human leukocyte antigen (HLA) between the donor and host. By 
      contrast, cord blood transplantation (CBT) is typically associated with low-grade 
      severity of aGVHD, but the underlying mechanisms remain unclear. Donor-derived 
      CD4(+) alloreactive T cells (ATs) are of a specific lymphocyte subset, which can 
      be activated by the recipient's HLA, and play a crucial role in the onset of 
      aGVHD. In the present study, we aimed to explore the difference in the property 
      of CD4(+) ATs between cord blood (CB) and adult peripheral blood (APB). We thus 
      found that CB and APB CD4(+) ATs contained not only effector T cells (Teffs) that 
      execute aGVHD, but also a distinct subset of FoxP3(+) regulatory T cells (Tregs) 
      that may alleviate aGVHD. Importantly, CB CD4(+) ATs contained higher percentage 
      of FoxP3(+) Tregs, compared to APB CD4(+) ATs (P < 0.001), while lower percentage 
      of Teffs (Th1, Th2 and Th17 cells) was detected in CB CD4(+) ATs (P < 0.05, P < 
      0.001 and P < 0.05, respectively). Our findings suggest that FoxP3(+) Tregs in CB 
      CD4(+) ATs may contribute to attenuating the severity of aGVHD observed after 
      CBT.
FAU - Zou, Xingli
AU  - Zou X
AD  - Department of Rheumatology and Hematology, Affiliated Hospital of North Sichuan 
      Medical College.
FAU - Lin, Xiaojing
AU  - Lin X
FAU - Luo, Wenfeng
AU  - Luo W
FAU - Wei, Jin
AU  - Wei J
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Interleukin-2 Receptor alpha Subunit)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Adult
MH  - Cell Proliferation
MH  - *Cord Blood Stem Cell Transplantation
MH  - Forkhead Transcription Factors/metabolism
MH  - Graft vs Host Disease/*immunology/*pathology
MH  - Humans
MH  - Interleukin-2 Receptor alpha Subunit/metabolism
MH  - Isoantigens/immunology
MH  - Lymphocyte Activation/immunology
MH  - Lymphocyte Subsets/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - *Tissue Donors
EDAT- 2016/07/01 06:00
MHDA- 2017/03/28 06:00
CRDT- 2016/07/01 06:00
PHST- 2016/07/01 06:00 [entrez]
PHST- 2016/07/01 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
AID - 10.1620/tjem.239.193 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2016 Jul;239(3):193-202. doi: 10.1620/tjem.239.193.