PMID- 27356547 OWN - NLM STAT- MEDLINE DCOM- 20171027 LR - 20220317 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 13 IP - 2 DP - 2017 Apr TI - Effects of maternal vitamin B12 supplementation on early infant neurocognitive outcomes: a randomized controlled clinical trial. LID - 10.1111/mcn.12325 [doi] LID - e12325 AB - Maternal nutritional status during pregnancy impacts fetal brain development. Vitamin B12 plays a vital role in neuronal development. However, findings from studies on the association between maternal B12 status and child cognitive functions have been inconsistent. We performed a randomized, placebo-controlled clinical trial of oral B12 supplementation (50 microg) beginning at <14 weeks of gestation through a 6-week post-partum. In the present study, we report the effects of maternal B12 supplementation on cognitive development in infants at 9 months of age on Bayley Scales of Infant Development-III (BSID-III). One hundred eighty-three pregnant women received vitamin B12, and 183 received placebo. Nine-month BSID-III development score was available in 178 infants. There were no significant differences in maternal sociodemographic characteristics and baseline biochemical measures between infants who underwent BSID-III evaluation and infants who were not evaluated. There were no significant differences in any of the subscales of BSID-III between infants born to mothers who received B12 supplementation (n = 78) vs. placebo (n = 100). On multiple regression analysis, elevated maternal total homocysteine (tHcy) levels adjusted for treatment group, birthweight, parity, income and home environment at second trimester of pregnancy were significantly negatively associated with expressive language (beta = 3.13 points, P < 0.001), and in third trimester of pregnancy with expressive language (beta = -2.29 points, P < 0.001) and fine motor (beta = -1.41 points, P = 0.005) domains of BSID-III. While no significant effects of maternal B12 supplementation were seen on cognitive development in infants at 9 months of age, elevated maternal tHcy levels were associated with poorer cognitive performance in some of the subdomains of BSID-III. In pregnant women with elevated tHcy levels and or B12 deficiencies, it may be worthwhile to study the impact of longer term maternal supplementation on infant cognitive outcomes. CI - (c) 2016 John Wiley & Sons Ltd. FAU - Srinivasan, Krishnamachari AU - Srinivasan K AD - Division of Mental Health and Neurosciences, St. John's Research Institute, Bengaluru, Karnataka, India. AD - Department of Psychiatry, St. John's Medical College, Bangalore, Karnataka, India. FAU - Thomas, Tinku AU - Thomas T AD - Division of Epidemiology, Biostatistics and Population Health, St. John's Research Institute, Bangalore, Karnataka, India. FAU - Kapanee, Aruna Rose Mary AU - Kapanee AR AD - Department of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. FAU - Ramthal, Asha AU - Ramthal A AD - Division of Mental Health and Neurosciences, St. John's Research Institute, Bengaluru, Karnataka, India. FAU - Bellinger, David C AU - Bellinger DC AD - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. FAU - Bosch, Ronald J AU - Bosch RJ AD - Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. FAU - Kurpad, Anura V AU - Kurpad AV AD - Division of Nutrition, St. John's Research Institute, Bangalore, Karnataka, India. AD - Department of Physiology, St. John's Medical College, Bangalore, Karnataka, India. FAU - Duggan, Christopher AU - Duggan C AD - Division of Nutrition, St. John's Research Institute, Bangalore, Karnataka, India. AD - Center for Nutrition, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. LA - eng GR - P30 DK040561/DK/NIDDK NIH HHS/United States GR - R03 HD054323/HD/NICHD NIH HHS/United States GR - R03 HD052143/HD/NICHD NIH HHS/United States GR - K24 DK104676/DK/NIDDK NIH HHS/United States GR - U54 HD090255/HD/NICHD NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20160629 PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Micronutrients) RN - 0LVT1QZ0BA (Homocysteine) RN - P6YC3EG204 (Vitamin B 12) SB - IM MH - Adult MH - Brain/embryology/*growth & development MH - Child Development MH - *Cognition MH - *Dietary Supplements MH - Double-Blind Method MH - Female MH - Fetal Development MH - Homocysteine/blood MH - Humans MH - India/epidemiology MH - Infant MH - Linear Models MH - *Maternal Nutritional Physiological Phenomena MH - Micronutrients/administration & dosage/blood MH - Nutritional Status MH - Pregnancy MH - Prenatal Exposure Delayed Effects MH - Prevalence MH - Socioeconomic Factors MH - Treatment Outcome MH - Vitamin B 12/*administration & dosage MH - Vitamin B 12 Deficiency/*epidemiology MH - Young Adult PMC - PMC6090548 MID - NIHMS974211 OTO - NOTNLM OT - antenatal nutrition OT - cognitive function OT - homocysteine OT - infants OT - maternal micronutrients OT - maternal vitamin B12 COIS- The authors declare that they have no conflicts of interest. EDAT- 2016/07/01 06:00 MHDA- 2017/10/28 06:00 PMCR- 2016/06/29 CRDT- 2016/07/01 06:00 PHST- 2015/10/21 00:00 [received] PHST- 2016/03/12 00:00 [revised] PHST- 2016/03/14 00:00 [accepted] PHST- 2016/07/01 06:00 [pubmed] PHST- 2017/10/28 06:00 [medline] PHST- 2016/07/01 06:00 [entrez] PHST- 2016/06/29 00:00 [pmc-release] AID - MCN12325 [pii] AID - 10.1111/mcn.12325 [doi] PST - ppublish SO - Matern Child Nutr. 2017 Apr;13(2):e12325. doi: 10.1111/mcn.12325. Epub 2016 Jun 29.