PMID- 27357901
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20180317
IS  - 1369-1651 (Electronic)
IS  - 0899-0220 (Linking)
VI  - 33
IP  - 2
DP  - 2016 Jun
TI  - SPARCL1-containing neurons in the human brainstem and sensory ganglion.
PG  - 112-7
LID - 10.1080/08990220.2016.1197115 [doi]
AB  - Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is a member of the 
      osteonectin family of proteins. In this study, immunohistochemistry for SPARCL1 
      was performed to obtain its distribution in the human brainstem, cervical spinal 
      cord, and sensory ganglion. SPARCL1-immunoreactivity was detected in neuronal 
      cell bodies including perikarya and proximal dendrites, and the neuropil. The 
      motor nuclei of the IIIrd, Vth, VIth, VIIth, IXth, Xth, XIth, and XIIth cranial 
      nerves and spinal nerves contained many SPARCL1-immunoreactive (-IR) neurons with 
      medium-sized to large cell bodies. Small and medium-sized SPARCL1-IR neurons were 
      distributed in sensory nuclei of the Vth, VIIth, VIIIth, IXth, and Xth cranial 
      nerves. In the medulla oblongata, the dorsal column nuclei also had small to 
      medium-sized SPARCL1-IR neurons. In addition, SPARCL1-IR neurons were detected in 
      the nucleus of the trapezoid body and pontine nucleus within the pons and the 
      arcuate nucleus in the medulla oblongata. In the cervical spinal cord, the 
      ventral horn contained some SPARCL1-IR neurons with large cell bodies. These 
      findings suggest that SPARCL1-containing neurons function to relay and regulate 
      motor and sensory signals in the human brainstem. In the dorsal root (DRG) and 
      trigeminal ganglia (TG), primary sensory neurons contained 
      SPARCL1-immunoreactivity. The proportion of SPARCL1-IR neurons in the TG 
      (mean +/- SD, 39.9 +/- 2.4%) was higher than in the DRG (30.6 +/- 2.1%). SPARCL1-IR 
      neurons were mostly medium-sized to large (mean +/- SD, 1494.5 +/- 708.3 mum(2); 
      range, 320.4-4353.4 mum(2)) in the DRG, whereas such neurons were of various cell 
      body sizes in the TG (mean +/- SD, 1291.2 +/- 532.8 mum(2); range, 
      209.3-4326.4 mum(2)). There appears to be a SPARCL1-containing sensory pathway in 
      the ganglion and brainstem of the spinal and trigeminal nervous systems.
FAU - Hashimoto, Naoya
AU  - Hashimoto N
AD  - a Division of Oral Diagnosis , Graduate School of Dentistry, Tohoku University , 
      Sendai , Japan ;
FAU - Sato, Tadasu
AU  - Sato T
AD  - b Division of Oral and Craniofacial Anatomy , Graduate School of Dentistry, 
      Tohoku University , Sendai , Japan ;
FAU - Yajima, Takehiro
AU  - Yajima T
AD  - c Division of Operative Dentistry , Graduate School of Dentistry, Tohoku 
      University , Sendai , Japan ;
FAU - Fujita, Masatoshi
AU  - Fujita M
AD  - d Division of Dental Anesthesiology and Pain Management , Graduate School of 
      Dentistry, Tohoku University , Sendai , Japan.
FAU - Sato, Ayumi
AU  - Sato A
AD  - b Division of Oral and Craniofacial Anatomy , Graduate School of Dentistry, 
      Tohoku University , Sendai , Japan ;
FAU - Shimizu, Yoshinaka
AU  - Shimizu Y
AD  - b Division of Oral and Craniofacial Anatomy , Graduate School of Dentistry, 
      Tohoku University , Sendai , Japan ;
FAU - Shimada, Yusuke
AU  - Shimada Y
AD  - a Division of Oral Diagnosis , Graduate School of Dentistry, Tohoku University , 
      Sendai , Japan ;
FAU - Shoji, Noriaki
AU  - Shoji N
AD  - a Division of Oral Diagnosis , Graduate School of Dentistry, Tohoku University , 
      Sendai , Japan ;
FAU - Sasano, Takashi
AU  - Sasano T
AD  - a Division of Oral Diagnosis , Graduate School of Dentistry, Tohoku University , 
      Sendai , Japan ;
FAU - Ichikawa, Hiroyuki
AU  - Ichikawa H
AD  - b Division of Oral and Craniofacial Anatomy , Graduate School of Dentistry, 
      Tohoku University , Sendai , Japan ;
LA  - eng
PT  - Journal Article
DEP - 20160629
PL  - England
TA  - Somatosens Mot Res
JT  - Somatosensory & motor research
JID - 8904127
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (SPARCL1 protein, human)
SB  - IM
MH  - Afferent Pathways
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Stem/*cytology/*metabolism
MH  - Calcium-Binding Proteins/*metabolism
MH  - Extracellular Matrix Proteins/*metabolism
MH  - Female
MH  - Ganglia, Sensory/*cytology
MH  - Humans
MH  - Male
MH  - Neurons
MH  - Spinal Cord/cytology
OTO - NOTNLM
OT  - SPARCL1
OT  - brainstem
OT  - human
OT  - immunohistochemistry
OT  - sensory ganglion
EDAT- 2016/07/01 06:00
MHDA- 2018/01/03 06:00
CRDT- 2016/07/01 06:00
PHST- 2016/07/01 06:00 [entrez]
PHST- 2016/07/01 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
AID - 10.1080/08990220.2016.1197115 [doi]
PST - ppublish
SO  - Somatosens Mot Res. 2016 Jun;33(2):112-7. doi: 10.1080/08990220.2016.1197115. 
      Epub 2016 Jun 29.