PMID- 27358552
OWN - NLM
STAT- MEDLINE
DCOM- 20170414
LR  - 20211204
IS  - 2413-7170 (Electronic)
IS  - 1029-1857 (Print)
IS  - 1029-1857 (Linking)
VI  - 26
IP  - 3
DP  - 2016 May
TI  - Immune Reconstitution Inflammatory Syndrome and Shingles Associated with a 
      Combined Paralysis of Three Oculomotor Nerves: A Case Report.
PG  - 297-300
AB  - BACKGROUND: In countries with high prevalence of HIV/AIDS infection, particularly 
      in black Africa, shingles is one of the main opportunistic infections during 
      immunosuppression due to AIDS in young patients. If immunological weakness is 
      important, usually when the CD4 cell count is less than 100 cells/mm(3), the risk 
      of inflammatory reactions in the first three months after initiating of 
      antiretroviral treatment (ART) is very high. This inflammatory reaction is called 
      immune reconstitution inflammatory syndrome (IRIS). This observation reports the 
      first documented case of IRIS with V1 shingles in a young HIV patient at 
      University Hospital of Brazzaville. CASE DETAILS: A 40 years old patient was seen 
      for a pain of the right side of the face and a complete immobility of the 
      eyeball. The diagnosis of V1 shingles with a pan uveitis, and a paralysis of III, 
      IV and VI nerves was made. The patiants HIV status was positive and CD4 cell 
      count was 150 cells/mm(3). After two months of evolution under ART with a CD4 
      count of 850 cells /mm(3), the symptomatology was quickly complicated by 
      significant inflammation causing a phtisis bulbi. CONCLUSION: CD4 cells count is 
      an important indicator in the HIV/AIDS therapy. In some major forms of IRIS, 
      momentary pause of anti retroviral treatment is sometimes necessary.
FAU - Atipo-Tsiba, P W
AU  - Atipo-Tsiba PW
AD  - Department of Ophthalmology, University Hospital of Brazzaville.
FAU - Kombo Bayonne, E S
AU  - Kombo Bayonne ES
AD  - Department of Medicinel (Dermatology unit), Talangai Hospital of Brazzaville.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Ethiopia
TA  - Ethiop J Health Sci
JT  - Ethiopian journal of health sciences
JID - 101224773
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/etiology
MH  - Adult
MH  - Anti-HIV Agents/adverse effects/therapeutic use
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - *CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes
MH  - Eye/pathology
MH  - HIV Infections/complications/*drug therapy
MH  - Herpes Zoster/*etiology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*pathology
MH  - Immunosuppression Therapy/*adverse effects
MH  - Inflammation/etiology
MH  - Male
MH  - Oculomotor Nerve/pathology
MH  - Oculomotor Nerve Diseases/*etiology
MH  - Uveitis/etiology
PMC - PMC4913199
OTO - NOTNLM
OT  - AIDS
OT  - Immune reconstitution Inflammatory Syndrome
OT  - Oculomotor Nerves Paralysis
OT  - Shingles
EDAT- 2016/07/01 06:00
MHDA- 2017/04/15 06:00
PMCR- 2016/05/01
CRDT- 2016/07/01 06:00
PHST- 2016/07/01 06:00 [entrez]
PHST- 2016/07/01 06:00 [pubmed]
PHST- 2017/04/15 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - jEJHS.v26.i3.pg297 [pii]
AID - 10.4314/ejhs.v26i3.14 [doi]
PST - ppublish
SO  - Ethiop J Health Sci. 2016 May;26(3):297-300. doi: 10.4314/ejhs.v26i3.14.