PMID- 27358858
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160630
LR  - 20200930
IS  - 2306-9759 (Print)
IS  - 2313-0792 (Electronic)
IS  - 2306-9759 (Linking)
VI  - 1
DP  - 2014
TI  - TNF-alpha, a good or bad factor in hematological diseases?
PG  - 12
LID - 10.3978/j.issn.2306-9759.2014.04.02 [doi]
LID - 12
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a highly pleiotropic cytokine involved in 
      a spectrum of physiological processes that control inflammation, anti-tumor 
      responses and homeostasis through two receptors, TNF-R1 and TNF-R2. In general, 
      TNF-R1 mediates cytotoxicity, resistance to infection and stimulation of NF-kappaB. 
      By contrast, TNF-R2 has been implicated in proliferation of T-cell line, 
      thymocytes and human mononuclear cells. Hematological malignancies are the types 
      of cancer that affect normal hematopoiesis, have a speedy development, high 
      lethal rate and until now still have no effective treatment. Several studies have 
      shown that inflammatory cytokines play an important role in the onset and 
      progress of these diseases. In this review, we summarize the recent studies and 
      evaluate the positive or negative role of TNF-alpha in some hematological 
      malignancies or diseases with a malignant tendency.
FAU - Tian, Tian
AU  - Tian T
AD  - Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, 
      China.
FAU - Wang, Min
AU  - Wang M
AD  - Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, 
      China.
FAU - Ma, Daoxin
AU  - Ma D
AD  - Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140601
PL  - China
TA  - Stem Cell Investig
JT  - Stem cell investigation
JID - 101672113
PMC - PMC4923506
OTO - NOTNLM
OT  - Tumor necrosis factor-alpha (TNF-alpha)
OT  - hematological diseases
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/06/01
CRDT- 2016/07/01 06:00
PHST- 2013/09/16 00:00 [received]
PHST- 2014/04/20 00:00 [accepted]
PHST- 2016/07/01 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - sci-01-2014.04.02 [pii]
AID - 10.3978/j.issn.2306-9759.2014.04.02 [doi]
PST - epublish
SO  - Stem Cell Investig. 2014 Jun 1;1:12. doi: 10.3978/j.issn.2306-9759.2014.04.02. 
      eCollection 2014.