PMID- 27364738
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20180111
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 31
IP  - 13
DP  - 2016 Nov
TI  - The Influence of Neurodevelopmental Treatment on Transforming Growth Factor-beta1 
      Levels and Neurological Remodeling in Children With Cerebral Palsy.
PG  - 1464-1467
AB  - Neurodevelopmental treatment is an advanced therapeutic approach for the neural 
      rehabilitation of children with cerebral palsy. Cerebral palsy represents a 
      spectrum of neurological disorders primarily affecting gross motor function. The 
      authors investigated the effects of neurodevelopmental treatment on serum levels 
      of transforming growth factor-beta1 (TGF-beta1), a neuroprotective cytokine, and 
      improvements to motor skills. Serum TGF-beta1 levels and total score of the Gross 
      Motor Function Measure-88 (GMFM-88) were significantly higher in children with 
      cerebral palsy who underwent neurodevelopmental treatment compared to untreated 
      patients (P < .01). Furthermore, the improved GMFM-88 total scores after 
      neurodevelopmental treatment were significantly higher in children under the age 
      of 3 with cerebral palsy than in older patients (P < .01). The authors 
      demonstrate that the integration of TGF-beta1 levels and GMFM-88 total score could 
      be used to assess the efficacy of neurodevelopmental treatment. Moreover, the 
      findings provide further scientific support for the early intervention and 
      neurological rehabilitation of young children with cerebral palsy.
CI  - (c) The Author(s) 2016.
FAU - Tao, Weiyuan
AU  - Tao W
AD  - Department of Neurology, Renmin Hospital of Wuhan University, Wuhan Hubei 
      Province, PR China.
FAU - Lu, Zuneng
AU  - Lu Z
AD  - Department of Neurology, Renmin Hospital of Wuhan University, Wuhan Hubei 
      Province, PR China 39801229@qq.com.
FAU - Wen, Fang
AU  - Wen F
AD  - Institute Neuopsychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      Province, PR China.
LA  - eng
PT  - Journal Article
DEP - 20160630
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
RN  - 0 (Biomarkers)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Biomarkers/blood
MH  - Cerebral Palsy/*physiopathology/*rehabilitation
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Motor Activity
MH  - *Neurological Rehabilitation
MH  - Severity of Illness Index
MH  - Transforming Growth Factor beta1/*blood
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Gross Motor Function Measure
OT  - TGF-beta1
OT  - cerebral palsy
OT  - neurodevelopmental treatment
OT  - remodeling
EDAT- 2016/07/02 06:00
MHDA- 2017/12/19 06:00
CRDT- 2016/07/02 06:00
PHST- 2015/10/20 00:00 [received]
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/07/02 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2016/07/02 06:00 [entrez]
AID - 0883073816656402 [pii]
AID - 10.1177/0883073816656402 [doi]
PST - ppublish
SO  - J Child Neurol. 2016 Nov;31(13):1464-1467. doi: 10.1177/0883073816656402. Epub 
      2016 Jun 30.