PMID- 2736719
OWN - NLM
STAT- MEDLINE
DCOM- 19890810
LR  - 20190510
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 10
IP  - 7
DP  - 1989 Jul
TI  - Comparative dose-response study on the pulmonary carcinogenicity of 
      1,6-dinitropyrene and benzo[a]pyrene in F344 rats.
PG  - 1285-90
AB  - The dose dependencies of the lung carcinogenicity of 1,6-dinitropyrene (1,6-DNP) 
      and benzo[a]pyrene (BaP) were examined by direct injections of these compounds 
      into rat lungs. A total of 276 male F344 rats were divided into 10 groups and 
      given various doses of 1,6-DNP or BaP, or no drug (control group). Both chemicals 
      were injected into the lung, as suspensions in beeswax--tricaprylin and the 
      animals were then observed for 104 weeks. The incidences of lung cancer were 0/39 
      (0%), 4/30 (13%), 13/31 (42%), 22/26 (85%) and 6/9 (67%) in groups treated with 
      0.003, 0.01, 0.03, 0.1 and 0.15 mg of 1,6-DNP respectively, and 1/29 (3%), 7/30 
      (23%), 22/29 (76%) and 9/13 (69%) in those treated with 0.03, 0.1, 0.3 and 1.0 mg 
      of BaP respectively. No lung cancer was found in control rats. Thus the 
      incidences of lung cancer induced by 1,6-DNP and BaP showed significant dose 
      dependence. At equal doses, the incidence of lung cancer was much higher with 
      1,6-DNP than with BaP, and the induction of cancer by 1,6-DNP was higher even at 
      one-third the dose of BaP. Histologically, most tumors induced by 1,6-DNP were 
      undifferentiated neoplasms, whereas most of those induced by BaP were 
      well-differentiated squamous cell carcinomas.
FAU - Iwagawa, M
AU  - Iwagawa M
AD  - Second Department of Pathology, School of Medicine, University of Tokushima, 
      Japan.
FAU - Maeda, T
AU  - Maeda T
FAU - Izumi, K
AU  - Izumi K
FAU - Otsuka, H
AU  - Otsuka H
FAU - Nishifuji, K
AU  - Nishifuji K
FAU - Ohnishi, Y
AU  - Ohnishi Y
FAU - Aoki, S
AU  - Aoki S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Carcinogens)
RN  - 0 (Pyrenes)
RN  - 3417WMA06D (Benzo(a)pyrene)
RN  - 66Q2ZUF83N (1,6-dinitropyrene)
SB  - IM
MH  - Animals
MH  - Benzo(a)pyrene/*toxicity
MH  - Body Weight/drug effects
MH  - Carcinogens/*toxicity
MH  - Carcinoma, Squamous Cell/*chemically induced/pathology
MH  - Dose-Response Relationship, Drug
MH  - Lung/drug effects/*pathology
MH  - Lung Neoplasms/*chemically induced/pathology
MH  - Male
MH  - Neoplasms, Experimental/pathology
MH  - Pyrenes/*toxicity
MH  - Rats
MH  - Rats, Inbred F344
MH  - Reference Values
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - 10.1093/carcin/10.7.1285 [doi]
PST - ppublish
SO  - Carcinogenesis. 1989 Jul;10(7):1285-90. doi: 10.1093/carcin/10.7.1285.