PMID- 27369472
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20220316
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 43
IP  - 2
DP  - 2017 Mar 1
TI  - Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High 
      Risk for Psychosis.
PG  - 449-458
LID - 10.1093/schbul/sbw086 [doi]
AB  - Most individuals at ultra-high risk (UHR) for psychosis do not transition to 
      frank illness. Nevertheless, many have poor clinical outcomes and impaired 
      psychosocial functioning. This study used voxel-based morphometry to investigate 
      if baseline grey and white matter brain densities at identification as UHR were 
      associated with functional outcome at medium- to long-term follow-up. 
      Participants were help-seeking UHR individuals (n = 109, 54M:55F) who underwent 
      magnetic resonance imaging at baseline; functional outcome was assessed an 
      average of 9.2 years later. Primary analysis showed that lower baseline grey 
      matter density, but not white matter density, in bilateral frontal and limbic 
      areas, and left cerebellar declive were associated with poorer functional outcome 
      (Social and Occupational Functioning Assessment Scale [SOFAS]). These findings 
      were independent of transition to psychosis or persistence of the at-risk mental 
      state. Similar regions were significantly associated with lower self-reported 
      levels of social functioning and increased negative symptoms at follow-up. 
      Exploratory analyses showed that lower baseline grey matter densities in middle 
      and inferior frontal gyri were significantly associated with decline in Global 
      Assessment of Functioning (GAF) score over follow-up. There was no association 
      between baseline grey matter density and IQ or positive symptoms at follow-up. 
      The current findings provide novel evidence that those with the poorest 
      functional outcomes have the lowest grey matter densities at identification as 
      UHR, regardless of transition status or persistence of the at-risk mental state. 
      Replication and validation of these findings may allow for early identification 
      of poor functional outcome and targeted interventions.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the Maryland 
      Psychiatric Research Center. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Reniers, Renate L E P
AU  - Reniers RL
AD  - School of Psychology, University of Birmingham, Birmingham, UK.
FAU - Lin, Ashleigh
AU  - Lin A
AD  - Telethon Kids Institute, The University of Western Australia, Perth, Australia.
FAU - Yung, Alison R
AU  - Yung AR
AD  - Institute of Brain Behaviour and Mental Health, University of Manchester, 
      Manchester, UK.
FAU - Koutsouleris, Nikolaos
AU  - Koutsouleris N
AD  - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of 
      Munich, Munich, Germany.
FAU - Nelson, Barnaby
AU  - Nelson B
AD  - Orygen, The National Centre of Excellence in Youth Mental Health, The University 
      of Melbourne, Melbourne, Australia.
FAU - Cropley, Vanessa L
AU  - Cropley VL
AD  - Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne 
      Health, Melbourne, Australia.
FAU - Velakoulis, Dennis
AU  - Velakoulis D
AD  - Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne 
      Health, Melbourne, Australia.
FAU - McGorry, Patrick D
AU  - McGorry PD
AD  - Orygen, The National Centre of Excellence in Youth Mental Health, The University 
      of Melbourne, Melbourne, Australia.
FAU - Pantelis, Christos
AU  - Pantelis C
AD  - Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne 
      Health, Melbourne, Australia.
AD  - Centre for Neural Engineering, Department of Electrical and Electronic 
      Engineering, University of Melbourne, Victoria, Australia.
AD  - Florey Institute for Neuroscience & Mental Health, Victoria, Australia.
FAU - Wood, Stephen J
AU  - Wood SJ
AD  - School of Psychology, University of Birmingham, Birmingham, UK.
AD  - Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne 
      Health, Melbourne, Australia.
LA  - eng
GR  - MR/K013599/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Gray Matter/*diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Prefrontal Cortex/*diagnostic imaging
MH  - Psychotic Disorders/*diagnostic imaging/*physiopathology
MH  - Risk
MH  - White Matter/diagnostic imaging
MH  - Young Adult
PMC - PMC5605267
OTO - NOTNLM
OT  - clinical high risk
OT  - functional outcome
OT  - grey matter density
OT  - negative symptoms
OT  - psychosis
OT  - ultra-high risk
OT  - voxel-based morphometry
EDAT- 2016/07/03 06:00
MHDA- 2017/07/25 06:00
PMCR- 2018/03/01
CRDT- 2016/07/03 06:00
PHST- 2016/07/03 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2016/07/03 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - sbw086 [pii]
AID - 10.1093/schbul/sbw086 [doi]
PST - ppublish
SO  - Schizophr Bull. 2017 Mar 1;43(2):449-458. doi: 10.1093/schbul/sbw086.